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Description:: The formation of a primary endocytic vesicle bud is a dynamic process involving the transient organization of adaptor and scaffold proteins at the plasma membrane. The proteins involved in early endocytosis have modular protein interaction motifs and domains that are predicted to contribute to scaffold formation. These motifs are found...
Keyword:: Cell Biology
Subject:: Interdepartmental Biological Sciences Program
Creator:: Michael Dores
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/03/2018
Date Modified:: 10/03/2018
Date Created:: 2008-07-15
Resource Type:: Dissertation

Description:: To maintain polarity, epithelial cells continuously sort transmembrane proteins to the apical or basolateral membrane domains during biosynthetic delivery or after internalization. This thesis was designed to elucidate the molecular mechanism underlying protein trafficking. Our studies identified Rab13 as a critical GTPase regulator of biosynthetic cargos that are transported from...
Keyword:: Cell Biology
Subject:: Interdepartmental Biological Sciences Program
Creator:: Rita Lynn Nokes
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/02/2018
Date Modified:: 10/02/2018
Date Created:: 2008-12-07
Resource Type:: Dissertation

Description:: Receptor tyrosine kinases (RTKs) play a fundamental role in cell growth, metabolism and survival. Altered cell surface expression of RTKs has profound effects on organismal physiology and is associated with both metabolic disease and neoplasia. The insulin receptor (IR) is a prototypical RTK that regulates metabolism and lifespan and as...
Keyword:: Cell Biology
Subject:: Interdepartmental Biological Sciences Program
Creator:: Maria Rowena Bernadette Rojas Ramos
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/27/2018
Date Modified:: 08/27/2018
Date Created:: 2007-12-07
Resource Type:: Dissertation

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