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Filtering by: Date created tesim 1/1/2018 Keyword Covalent Resource type Dissertation

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Description:: The FDA approvals of afatinib and ibrutinib in 2013 led to a heightened interest in cysteine-reactive covalent inhibitors. However, there are few methods to discover new cysteine-reactive inhibitors for enzymes for which reversible binding scaffolds are not known. To this end, we rationally designed a chemical system to attach a...
Keyword:: Electrophile, Covalent, Fragment, Ubiquitin, and Nedd4-1
Subject:: Chemistry
Creator:: Stefan Kathman
Owner:: Scholarly Digital Publishing
Date Uploaded:: 02/19/2018
Date Modified:: 02/19/2018
Date Created:: 2016-01-01
Resource Type:: Dissertation

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