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Filtering by: Keyword ER stress Resource type Dissertation

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Lipid unsaturation in ovarian cancer

Description:

Fat represents an important source of energy for ovarian cancer (OC) cells and is supplied either through import from the tumor milieu or via de novo lipogenesis. During fast tumor growth, when nutrients are scarce, lipogenesis becomes the primary source of fatty acids. Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in...

Keyword:

ER stress, Fatty acids, Ovarian cancer, and Lipid metabolism

Subject:

Bioinformatics, Oncology, and Cellular biology

Creator:

Zhao, Guangyuan

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_940639 and http://dissertations.umi.com/northwestern:16324
The Role of Alpha-Synuclein Aggregation in Endoplasmic Reticulum Protein Folding and Homeostasis

Description:

Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...

Keyword:

induced pluripotent stem cell models, ER stress, protein aggregation, protein folding, and lysosomal dysfunction

Subject:

Molecular biology and Neurosciences

Creator:

Stojkovska, Iva

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_850723 and http://dissertations.umi.com/northwestern:15793

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Lipid unsaturation in ovarian cancer

The Role of Alpha-Synuclein Aggregation in Endoplasmic Reticulum Protein Folding and Homeostasis

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