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The Role of the Host Response and Viral Genetic Variation in the Pathogenesis of Herpes Simplex Encephalitis

Description:

Herpes simplex virus (HSV) encephalitis (HSE) is the most common cause of sporadic fatal encephalitis, and despite targeted antiviral therapy, outcomes remain poor. While rare in adults, neonates are significantly more susceptible to severe HSV disease. Understanding both the host and viral factors that contribute to pathogenesis is critical to...

Keyword:

Inflammasome, Neonate, Encephalitis, and Herpes

Subject:

Virology, Immunology, and Neurosciences

Creator:

Hayes, Cooper Kincaid

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_903123 and http://dissertations.umi.com/northwestern:16088
Role of the Type I IFN Response in Age-dependent Pathogenesis of HSV Encephalitis

Description:

Newborns are particularly susceptible to severe forms of herpes simplex virus type I (HSV-1) infection including encephalitis and multisystemic disseminated disease. The underlying age-dependent differences in the immune response that explain this increased susceptibility relative to the adult population remain largely understudied. Evidence from animal studies and genetic studies in...

Keyword:

Interferon Response, HSV, Neonatal Immunity, and Encephalitis

Subject:

Virology and Immunology

Creator:

Giraldo Perez, Daniel

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15674 and etdadmin_upload_838287

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The Role of the Host Response and Viral Genetic Variation in the Pathogenesis of Herpes Simplex Encephalitis

Role of the Type I IFN Response in Age-dependent Pathogenesis of HSV Encephalitis

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