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Targeted Covalent Inhibition of Telomerase And Development of New Methods Involving Photoredox Catalysis

Description:

Chapter 1: Telomerase is a ribonucleoprotein enzyme that counteracts the shortening of telomeres by catalyzing the addition of nucleotides to the 3’ ends of chromosomes, resulting in telomerase inhibition attracting interest as a strategy for cancer. Telomerase has also been implicated in other tumorigenic pathways such as DNA damage repair,...

Keyword:

Natural product-inspired small molecules, Sequential Catalysis, Telomerase, Photoredox, Enzymatic Catalysis, and Cooperative Catalysis

Subject:

Organic chemistry

Creator:

Betori, Richard C

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

04/29/2020

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14978 and etdadmin_upload_716438