Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Epigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic...
Keyword:: Biological sciences, Histone methylation, Proteomics, Mass spectrometry, Protein interaction, and Epigenetics
Subject:: Analytical chemistry, Molecular biology, and Biochemistry
Creator:: Huang, Xiaoxiao
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_686355 and http://dissertations.umi.com/northwestern:14838

Description:: In nearly all Eukaryotes, the membrane-enclosed nucleus contains the vast majority of the cellular genome. Within this sub-cellular compartment, the nuclear architecture facilitates genomic chromatin organization. Controlling chromosomal loci’s spatial positioning relative to subnuclear structures and each other can have local and global effects on gene expression. Moreover, chromatin organization...
Keyword:: Genome, Yeast, Statistics, Nucleus, Epigenetics, and Diffusion
Subject:: Molecular biology, Genetics, and Biophysics
Creator:: Sumner, Michael Chas
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15670 and etdadmin_upload_837750

Description:: The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is implicated in active transcription. Here we show that DOT1L is overexpressed in Prostate cancer (PCa) and is associated with poor clinical outcome. Genetic and chemical inhibition of DOT1L selectively impaired viability of androgen receptor (AR)-signaling competent PCa...
Keyword:: Prostate Cancer, DOT1L, and Epigenetics
Subject:: Molecular biology and Oncology
Creator:: Vatapalli, Rajita
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 04/29/2020
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14971 and etdadmin_upload_714534

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