Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Aging is the greatest known risk factor for Alzheimer’s Disease (AD); however, the molecular mechanisms underlying aging and how it can initiate and or exacerbate AD, is still unknown. Epigenetic regulation has been widely accepted to play an essential role in aging or AD-related processes; however, whether dysregulations of histone...
Keyword:: HDACs, Alzheimer's Disease, Epigenetics, and Aging
Subject:: Neurosciences
Creator:: McClarty, Bryan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_954939 and http://dissertations.umi.com/northwestern:16390

Description:: Aging is the greatest known risk factor for Alzheimer’s Disease (AD); however, the molecular mechanisms underlying aging and how it can initiate and or exacerbate AD, is still unknown. Epigenetic regulation has been widely accepted to play an essential role in aging or AD-related processes; however, whether dysregulations of histone...
Keyword:: HDACs, Alzheimer's Disease, Epigenetics, and Aging
Subject:: Neurosciences
Creator:: McClarty, Bryan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 03/24/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_954939 and http://dissertations.umi.com/northwestern:16390

Description:: In nearly all Eukaryotes, the membrane-enclosed nucleus contains the vast majority of the cellular genome. Within this sub-cellular compartment, the nuclear architecture facilitates genomic chromatin organization. Controlling chromosomal loci’s spatial positioning relative to subnuclear structures and each other can have local and global effects on gene expression. Moreover, chromatin organization...
Keyword:: Genome, Yeast, Statistics, Nucleus, Epigenetics, and Diffusion
Subject:: Molecular biology, Genetics, and Biophysics
Creator:: Sumner, Michael Chas
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15670 and etdadmin_upload_837750

Description:: Human complex diseases such as common cancers and diabetes are characterized by high molecular heterogeneity contributed by both genetic and non- genetic factors. This molecular heterogeneity can not only complicate diagnosis, risk stratification and patient care, but also lead to differential therapeutic response and treatment efficiency. Therefore, understanding the molecular...
Keyword:: Complex disease , Cancer , Diabetes, Precision medicine , and Epigenetics
Subject:: Epidemiology and Bioinformatics
Creator:: Zeng, Chang
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15643 and etdadmin_upload_832581

Description:: Iron is an essential nutrient and is critical for cellular growth and metabolism. Here, we delineate a novel mechanism by which iron alters amino acid homeostasis and mTOR activity by remodeling the cellular epigenetic landscape. We find that iron deficiency inactivates Jumonji-C domain containing histone-demethylases, resulting in histone hyper-methylation and...
Keyword:: Iron, Epigenetics, Mitophagy, Metabolism, and mTOR
Subject:: Cellular biology
Creator:: Shapiro, Jason Solomon
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15209 and etdadmin_upload_759499

Description:: The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is implicated in active transcription. Here we show that DOT1L is overexpressed in Prostate cancer (PCa) and is associated with poor clinical outcome. Genetic and chemical inhibition of DOT1L selectively impaired viability of androgen receptor (AR)-signaling competent PCa...
Keyword:: Prostate Cancer, DOT1L, and Epigenetics
Subject:: Molecular biology and Oncology
Creator:: Vatapalli, Rajita
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 04/29/2020
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14971 and etdadmin_upload_714534

Description:: Epigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic...
Keyword:: Biological sciences, Histone methylation, Proteomics, Mass spectrometry, Protein interaction, and Epigenetics
Subject:: Analytical chemistry, Molecular biology, and Biochemistry
Creator:: Huang, Xiaoxiao
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_686355 and http://dissertations.umi.com/northwestern:14838

Description:: FOXA1 is a FKHD family protein that plays pioneering roles in lineage-specific enhancer activation and gene transcription. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically,...
Keyword:: Prostate cancer, TET1, Epigenetics, and FOXA1
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Yeqing (Angela) Yang
Owner:: Scholarly Digital Publishing
Date Uploaded:: 03/26/2018
Date Modified:: 01/29/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

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