Gene regulatory networks contain multiple components including microRNAs (miRNAs) that coordinate regulation of genes to produce higher level cell functions. miRNAs are small non-coding RNA molecules that modulate gene expression post-transcriptionally by binding to short target motifs on mRNA transcripts to down-regulate target genes. Because miRNA regulation of genes is...
In mammalian development, cell specification and organogenesis are achieved by the regulated expression and repression of specific subsets of genes. The anterior pituitary gland, comprised of five cell types that arise from a common precursor, is an excellent model system for understanding these developmental processes. Examination of factors regulating transcription...