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Sub-diffusion and Compartmentalization: How the Nuclear Pore Complex and Stochastic Movement are Utilized to Dynamically Organize the Eukaryotic Genome

Description:

In nearly all Eukaryotes, the membrane-enclosed nucleus contains the vast majority of the cellular genome. Within this sub-cellular compartment, the nuclear architecture facilitates genomic chromatin organization. Controlling chromosomal loci’s spatial positioning relative to subnuclear structures and each other can have local and global effects on gene expression. Moreover, chromatin organization...

Keyword:

Genome, Yeast, Statistics, Nucleus, Epigenetics, and Diffusion

Subject:

Molecular biology, Genetics, and Biophysics

Creator:

Sumner, Michael Chas

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15670 and etdadmin_upload_837750
Spatial Polarity of Human Genes within Nuclei and Its Relationship to Cellular Organization

Description:

The blueprint of life is contained within the sequence of an organism’s genome. While virtually all cells of an individual multicellular eukaryotic organism contain a near identical code of nucleic acid sequences, an organism must give rise to and maintain a varied set of cells and phenotypes. As such, sequence...

Keyword:

Genome, Epidermal Differentiation, Nuclear Organization, and Transcription

Subject:

Molecular biology, Genetics, and Cellular biology

Creator:

Garza-Gongora, Arturo

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_617313 and http://dissertations.umi.com/northwestern:14401

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Sub-diffusion and Compartmentalization: How the Nuclear Pore Complex and Stochastic Movement are Utilized to Dynamically Organize the Eukaryotic Genome

Spatial Polarity of Human Genes within Nuclei and Its Relationship to Cellular Organization

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