Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Glioblastoma (GBM) is the most common aggressive primary malignant brain tumorin adults with a median age of onset of 65 years of age. Although advanced age is often associated with worse GBM patient survival, the predominant source(s) of maladaptive aging effects remains to be established. Here we studied intra-tumoral and...
Keyword:: Senescence, p16INK4a, Glioblastoma, Aging, and Immunotherapy
Subject:: Biology and Neurosciences
Creator:: Bell, April Charlotte
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16795 and etdadmin_upload_1016132

Description:: Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...
Keyword:: GBM, Spherical nucleic acids, cGAS, Immunotherapy, and STING
Subject:: Biology, Biochemistry, and Immunology
Creator:: Mahajan, Akanksha Sanjay
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_983546 and http://dissertations.umi.com/northwestern:16516

Description:: Cell-based therapies are an exciting frontier in medicine. This field is built on a simple premise—cells can be engineered to recognize and treat various human diseases. The paradigm of cell-based therapy uses biosensors to interrogate a cell’s environment and distinguish disease from health, intracellular signaling pathways and genetic circuitry to...
Keyword:: Cell-based therapy, Synthetic receptors, Synthetic biology, Biosensors, Transcription factors, and Immunotherapy
Subject:: Bioengineering, Biology, and Medicine
Creator:: Donahue, Patrick Sean
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Modified:: 05/06/2022
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15420 and etdadmin_upload_781062

Description:: Intestinal immunity is a critical contributor to host health. The immune system in the intestine maintains both defense against pathogens and homeostasis of intestinal tissue, which is exposed to environmental influences, including microbes and ingested foods. Proper regulation of the immune response is required to prevent damage to the host....
Keyword:: Bioengineering, Host-Microbiome, Regulation, Immunotherapy, and Immunity
Subject:: Bioengineering, Medicine, and Immunology
Creator:: Bostick, John
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_661070 and http://dissertations.umi.com/northwestern:14597

Description:: T-cell activation is an essential step of the immune response, yet the cellular and molecular events underlying this complex process are not fully understood. Significantly, a comparative genome-scale transcriptional analysis of two T-cell subsets and the natural-mixed CD3+ population remains unexplored. Using microarrays, we investigated the temporal global transcriptional profile...
Keyword:: cell culture, Genome-Scale Transcription Profiling, Immunology, Immune Response, Immunotherapy, and T-cell
Subject:: Chemical and Biological Engineering
Creator:: Min Wang
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/19/2018
Date Modified:: 09/19/2018
Date Created:: 2008-11-03
Resource Type:: Dissertation

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