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Extracellular Nucleotide Regulation of Airway Epithelial Cell Immunological Mediator Release

Description:

The airway epithelial cells (AECs) lining the conducting passageways of the lung secrete a variety of immunomodulatory factors. One interesting pair of molecules produces by AECs is IL-6 and prostaglandin E2 (PGE2). PGE2 limits lung inflammation and promotes bronchodilation. By contrast, IL-6 drives intense airway inflammation, remodeling, and fibrosis. The...

Keyword:

Airway Epithelial Cells, Purinergic Signaling, Interferon, and CRAC channels

Subject:

Pharmacology and Immunology

Creator:

Kountz, Timothy

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15956 and etdadmin_upload_883223
Improving virus-specific immunity by IFN-I modulation

Description:

Vaccines, such as those against smallpox virus, polio virus, and yellow fever virus, have saved millions of lives. However, many infectious diseases, such as HIV-1, still lack a preventive vaccine. In addition, various vaccines, such as those against Influenza and SARS-CoV-2 require boosters and may not confer 100% lifelong protection...

Keyword:

Vaccines, Interferon, Virus, IFN-I, and Immunity

Subject:

Immunology

Creator:

Palacio Betancur, Nicole Maria

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_861407 and http://dissertations.umi.com/northwestern:15849

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Extracellular Nucleotide Regulation of Airway Epithelial Cell Immunological Mediator Release

Improving virus-specific immunity by IFN-I modulation

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