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Description:: Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...
Keyword:: iPSC, Interorganelle contacts, GBA, Lysosome, Mitochondria, and Parkinson's disease
Subject:: Molecular biology, Cellular biology, and Neurosciences
Creator:: Kim, Soojin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_825288 and http://dissertations.umi.com/northwestern:15606

Description:: Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
Keyword:: Imaging, Contact Sites, Lysosome, Mitochondria, Neurological Disease, and Calcium
Subject:: Biology, Medicine, and Neurosciences
Creator:: Peng, Wesley J
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15610 and etdadmin_upload_827420

Description:: Frontotemporal dementia (FTD) encompasses a group of neurodegenerative disorders characterized by cognitive and behavioral impairments. Heterozygous mutations in progranulin (PGRN) cause familial FTD and result in decreased PGRN expression, while homozygous mutations result in complete loss of PGRN expression and lead to the neurodegenerative lysosomal storage disorder neuronal ceroid lipofuscinosis...
Keyword:: Progranulin, Frontotemporal Dementia, Lysosome, and Cathepsin D
Subject:: Neurosciences
Creator:: Valdez, Clarissa
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2017-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14449 and etdadmin_upload_626172

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