Northwestern University

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Filtering by: Keyword Mitochondria Keyword Reactive oxygen species Subject Health sciences

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Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

Description:

Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cancer cells is not fully understood. To address this, we conducted a metabolism-focused CRISPR/Cas9 genetic screen and uncovered that loss of genes encoding...

Keyword:

Reactive oxygen species, Cancer, Mitochondria, and Metabolism

Subject:

Biology, Health sciences, and Medicine

Creator:

Kong, Hyewon

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_775698 and http://dissertations.umi.com/northwestern:15362