Index Catalog // Arch : Northwestern University Institutional Repository

Investigating MTCH2 as a genetic modifier of cardiomyopathy

Description:: Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant...
Keyword:: Heart Failure, Glucose, Cardiomyopathy, Drosophila, Metabolism, and Mitochondria
Subject:: Molecular biology, Gender studies, and Cellular biology
Creator:: Fischer, Julie Anne
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16326 and etdadmin_upload_941216

Coordinated Partitioning of Essential Organelles by a Mitochondrial Membrane Contact Site

Description:: Membrane contact sites (MCSs) facilitate communication and organization of organelles that contribute to fundamental cellular processes. It has become increasingly appreciated how extensive and essential MCSs are for cellular health, and this field is rapidly growing. We use budding yeast as a model system to study the mechanisms of how...
Keyword:: Membrane Contact Sites, Organelle Positioning, and Mitochondria
Subject:: Cellular biology
Creator:: Anderson, Heidi Lynn
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_873821 and http://dissertations.umi.com/northwestern:15900

Misregulation of Mitochondria-Lysosome Contact Sites in GBA-linked Parkinson’s Disease

Description:: Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...
Keyword:: iPSC, Interorganelle contacts, GBA, Lysosome, Mitochondria, and Parkinson's disease
Subject:: Molecular biology, Cellular biology, and Neurosciences
Creator:: Kim, Soojin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_825288 and http://dissertations.umi.com/northwestern:15606

Novel Functions of Mitochondria-Lysosome Contact Sites in Health and Neurological Disease

Description:: Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
Keyword:: Imaging, Contact Sites, Lysosome, Mitochondria, Neurological Disease, and Calcium
Subject:: Biology, Medicine, and Neurosciences
Creator:: Peng, Wesley J
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15610 and etdadmin_upload_827420

Mitochondrial Complex I Function in Leigh Syndrome and Aging.

Description:: Mitochondrial complex I is the primary entry point for electrons into the mitochondrial electron transport chain that is composed of 45 individual protein subunits that are encoded in both the nuclear and mitochondrial genomes. Mitochondrial complex I sits at an important nexus in the essential bioenergetic, biosynthetic, and signaling functions...
Keyword:: NDI1, NDUFS2, NDUFS4, Mitochondria, Leigh Syndrome, and Metabolism
Subject:: Biology, Aging, and Neurosciences
Creator:: McElroy, Gregory Scott
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_746970 and http://dissertations.umi.com/northwestern:15152

HEXOKINASE 1 SUBCELLULAR LOCALIZATION REGULATES THE METABOLIC FATE OF GLUCOSE

Description:: The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...
Keyword:: Inflammation, Hexokinase, Macrophage, Subcellular localization, Metabolism, and Mitochondria
Subject:: Biology
Creator:: De Jesus, Adam
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_773389 and http://dissertations.umi.com/northwestern:15348

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

Description:: Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cancer cells is not fully understood. To address this, we conducted a metabolism-focused CRISPR/Cas9 genetic screen and uncovered that loss of genes encoding...
Keyword:: Reactive oxygen species, Cancer, Mitochondria, and Metabolism
Subject:: Biology, Health sciences, and Medicine
Creator:: Kong, Hyewon
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_775698 and http://dissertations.umi.com/northwestern:15362

Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis

Description:: Endothelial cells (ECs) require glycolysis for proliferation and migration during angiogenesis; however, the necessity for the mitochondrial respiratory chain during angiogenesis is not known. In this study, we report that inhibition of respiratory chain complex III impairs proliferation, but not migration of ECs in vitro by decreasing the NAD+/NADH ratio....
Keyword:: Angiogenesis and Mitochondria
Subject:: Cellular biology
Creator:: Diebold, Lauren P
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_622203 and http://dissertations.umi.com/northwestern:14421

Molecular and Computational Studies of TDP-43 and FUS Proteinopathies

Description:: Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...
Keyword:: microRNA, Compositional Data Analysis, TDP-43 Proteinopathy, FUS Proteinopathy, RNA-Seq, and Mitochondria
Subject:: Molecular biology, Bioinformatics, and Neurosciences
Creator:: McGee, Warren A
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14675 and etdadmin_upload_663037

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Investigating MTCH2 as a genetic modifier of cardiomyopathy

Coordinated Partitioning of Essential Organelles by a Mitochondrial Membrane Contact Site

Misregulation of Mitochondria-Lysosome Contact Sites in GBA-linked Parkinson’s Disease

Novel Functions of Mitochondria-Lysosome Contact Sites in Health and Neurological Disease

Mitochondrial Complex I Function in Leigh Syndrome and Aging.

HEXOKINASE 1 SUBCELLULAR LOCALIZATION REGULATES THE METABOLIC FATE OF GLUCOSE

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis

Molecular and Computational Studies of TDP-43 and FUS Proteinopathies

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