Nanocarriers are drug delivery vehicles that have at least one dimension at the nanoscale (10-9 m). Engineering the nanocarrier surface is a strategy for targeting drug delivery to specific cell types to enhance efficacy and minimize side effects. A useful analogy is to consider how the chassis of an automotive...
Biological therapeutics have revolutionized the way we treat cancer due to their ability to target tumors discriminately, leaving healthy cells unaffected. However, our inability to tailor the structure of biologics may hamper their optimization for efficacy. This lack of programmability contributes to factors such as immunogenic responses, inability to penetrate...
Spinal cord injury (SCI) is a devastating injury, which can be caused by motor vehicle accidents, violence, and non-traumatic causes. These injuries can leave patients with lifelong paralysis, as well as incontinence and life threatening autonomic dysreflexia. There is currently no FDA approved treatment for SCI. Spinal injury disrupts the...
Over the past decade significant advancements have been made across the field of cancer biology resulting in transformative new therapies. Despite these advancements, treatments for metastatic cancer remain relatively ineffective. Metastasis is coordinated by various types of “healthy†stromal cells in addition to the tumor cells themselves. This requires a...
Graphene oxide (GO), a product of oxidative exfoliation of graphite powders, has received significant attention due to its excellent solution dispersibility, rich functionality, and ease of conversion to chemically modified graphene (also known as œreduced graphene oxide or œr-GO). These properties make GO an attractive building block for constructing various...
The assembly of nanoscale building blocks into larger ensembles with well-defined architecture has the potential to create entirely new classes of designer photonic and plasmonic metamaterials with unique properties not found in nature. Electromagnetic metasurfaces, or 2D metamaterials, operating at optical wavelengths are of particular interest due to ease of...
This project is comprised of primary source research on the field of semiconductor microscopy. We were interested in determining a more interdisciplinary application of this technology, as the most frequently cited applications are for defense purposes such as drug screening or infrared imaging. When we researched, we found that these...
The projected increase in the use of nanomaterials raises concerns about adverse impacts new technologies utilizing these materials may have on the environment. These concerns can be addressed from a chemical perspective by studying how emerging nanomaterials interact with biological systems. Fundamentally, the key interactions for nanomaterial uptake into a...
Plasmonic nanostructures are capable of trapping and confining light at the nanoscale, leading to interesting optical phenomena involving enhanced light-matter interactions. These responses arise in two forms: surface plasmon polaritons propagating on the surface of metal films and localized surface plasmons confined to the surface of metal nanoparticles. Plasmonic modes...
Spinal cord injury occurs with a worldwide incidence of 13-33 cases per million per year, and more than 2.5 million patients worldwide suffer from spinal cord injury (SCI)-related disability (1, 2). Different methods have been attempted to promote axonal regeneration, including neurotrophin injection, hydrogel injection, olfactory ensheathing cells implantation and...
