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Filtering by: Keyword Notch Resource type Dissertation

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Defining the role of Ikaros as a tumor suppressor and repressor of Notch target gene expression

Description:

Inactivation of tumor suppressors genes, which encode regulatory proteins critical for maintaining normal cellular function, is a common occurrence in cancer. Ikaros is a hematopoietic-specific zinc finger protein that functions as a differentiation regulator and has properties of a tumor suppressor. Ikaros functions to regulate gene expression as a component...

Keyword:

Notch, Ikaros, tumor suppressor, and RBP-J

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Katie L Kathrein

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/01/2018

Date Modified:

09/01/2018

Date Created:

2008-02-22

Resource Type:

Dissertation
Role of Notch and BMP Signaling Mediators in Neurogenesis

Description:

The nervous system develops through the highly regulated process of proliferation and differentiation of neural stem cells. Two major regulatory pathways that maintain neural stem cells in a proliferative state or promote their differentiation are the Notch and BMP signaling pathways, respectively. In this dissertation, we demonstrate that HeyL, a...

Keyword:

Notch, ,BMP, Heyl, Dandy-Walker, PAX3, and Cephalocele

Subject:

Neuroscience Institute Graduate Program

Creator:

Ali Jalali

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/07/2018

Date Modified:

08/07/2018

Date Created:

2007-10-11

Resource Type:

Dissertation