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Filtering by: Keyword Notch Subject Integrated Graduate Program in the Life Sciences

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Defining the role of Ikaros as a tumor suppressor and repressor of Notch target gene expression

Description:

Inactivation of tumor suppressors genes, which encode regulatory proteins critical for maintaining normal cellular function, is a common occurrence in cancer. Ikaros is a hematopoietic-specific zinc finger protein that functions as a differentiation regulator and has properties of a tumor suppressor. Ikaros functions to regulate gene expression as a component...

Keyword:

Notch, Ikaros, tumor suppressor, and RBP-J

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Katie L Kathrein

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/01/2018

Date Modified:

09/01/2018

Date Created:

2008-02-22

Resource Type:

Dissertation