Northwestern University

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Filtering by: Keyword Protein Degradation Keyword Proteomics Keyword Synaptic Vesicles

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Pulse-Chase Proteomics of Alzheimer’s Disease Models Reveals Synaptic Dysfunction Originates in Presynaptic Terminals

Description:

Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); however, little is known about the early mechanisms that contribute to this process. To objectively assess protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we used dynamic metabolic labeling with stable isotopes followed by proteomic...

Keyword:

Synaptic Vesicles, Alzheimer's Disease, Presynapse, Proteomics, and Protein Degradation

Subject:

Neurosciences

Creator:

Hark, Timothy

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15385 and etdadmin_upload_780177