Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Perturbations to the physiology or impairments in the formation of synapses within the cochlea, specifically the ribbon synapses, result in decreased sensitivity to auditory stimuli. In example, prolonged exposure to moderately intense auditory stimuli, like power tools, can result in the swelling of nerve terminals, retraction of the postsynaptic membrane,...
Keyword:: Hearing, Neuroligins, Proteomics, Ribbon Synapse, ASD, and NIHL
Subject:: Neurosciences
Creator:: Ramirez, Miguel Angel
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16120 and etdadmin_upload_909763

Description:: Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); however, little is known about the early mechanisms that contribute to this process. To objectively assess protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we used dynamic metabolic labeling with stable isotopes followed by proteomic...
Keyword:: Synaptic Vesicles, Alzheimer's Disease, Presynapse, Proteomics, and Protein Degradation
Subject:: Neurosciences
Creator:: Hark, Timothy
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15385 and etdadmin_upload_780177

Description:: Epigenetics is the study of chromatin-based events that regulate gene expression without the change of DNA sequence, including DNA methylation, histone modification and chromatin remodeling. Epigenetic regulators are encoded to modify chromatin in a highly regulated and dynamic manner. A growing number of studies have suggested the dysregulation of epigenetic...
Keyword:: Biological sciences, Histone methylation, Proteomics, Mass spectrometry, Protein interaction, and Epigenetics
Subject:: Analytical chemistry, Molecular biology, and Biochemistry
Creator:: Huang, Xiaoxiao
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_686355 and http://dissertations.umi.com/northwestern:14838

Description:: What follows is a strictly post-genomic dissertation. Over the past five years, I have strived to leave the nucleus behind, and even the endoplasmic reticulum and golgi apparatus. The human genome was sequenced over 15 years before the submission of this document, and the world changed somewhat less than anticipated—besides...
Keyword:: Top-Down Proteomics, Proteomics, Transplantation, Immunology, Mass Spectrometry, and Proteoforms
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Tinothy Toby
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/25/2019
Date Modified:: 01/25/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

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