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Description:: Pseudomonas aeruginosa is an important gram-negative opportunistic pathogen whose large genome allows it to thrive in diverse environments. There is a wide range of phenotypic variation within the species, which can be attributed both to variation in sequences present in most isolates (the core genome) or the presence or absence...
Keyword:: Pseudomonas aeruginosa, antimicrobial resistance, machine learning, virulence, and genomics
Subject:: Microbiology
Creator:: Pincus, Nathan Benjamin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15326 and etdadmin_upload_770712

Description:: Pseudomonas aeruginosa is a Gram-negative pathogen that frequently causes severe nosocomial infections through expression of virulence factors, evasion of immune clearance and resistance to therapeutic antimicrobial agents. These factors have led the US Centers for Disease Control and Prevention (CDC) and Infectious Disease Society of America (IDSA) to identify P....
Keyword:: Pseudomonas aeruginosa, antibiotic resistance, T3SS, and inflammasome
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Ami Joy Hughes
Owner:: Scholarly Digital Publishing
Date Uploaded:: 03/07/2019
Date Modified:: 03/07/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Description:: The Pseudomonas aeruginosa type III secretion system delivers effector proteins directly into target cells, allowing the bacterium to modulate host cell functions. ExoU is the most cytotoxic of the known effector proteins and has been associated with more severe infections in humans. Previous studies have shown that ExoU is a...
Keyword:: Pseudomonas aeruginosa, ExoU, and oligomerization
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Angelica Zhang
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/18/2019
Date Modified:: 01/18/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

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