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CD95/Fas ligand mRNA is toxic to cells through multiple mechanisms

Description:

CD95/Fas ligand (CD95L) is a well characterized activator of extrinsic apoptosis. CD95L protein binds to its cognate receptor, CD95/Fas/APO-1, inducing apoptotic signaling in sensitive cells. However, expression of CD95L is toxic even in the absence of CD95. We previously reported that the CD95L open reading frame (ORF) is enriched for...

Keyword:

FasL, RNA toxicity, RNA interference, and Cell death

Subject:

Molecular biology

Creator:

Haluck-Kangas, Ashley

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

05/31/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16384 and etdadmin_upload_949365
CD95/Fas ligand mRNA is toxic to cells through multiple mechanisms

Description:

CD95/Fas ligand (CD95L) is a well characterized activator of extrinsic apoptosis. CD95L protein binds to its cognate receptor, CD95/Fas/APO-1, inducing apoptotic signaling in sensitive cells. However, expression of CD95L is toxic even in the absence of CD95. We previously reported that the CD95L open reading frame (ORF) is enriched for...

Keyword:

FasL, RNA toxicity, RNA interference, and Cell death

Subject:

Molecular biology

Creator:

Haluck-Kangas, Ashley

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

03/24/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16384 and etdadmin_upload_949365

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CD95/Fas ligand mRNA is toxic to cells through multiple mechanisms

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