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Mechanisms of RNA Mediated Silencing in S. pombe

Description:

Mechanisms of RNA Mediated Silencing in S. pombe Christina A. Lawrence Heterochromatin of eukaryotic genomes has classically been defined as condensed chromatin that is repressive to transcription and typically resides at highly repetitive regions of the genome. Genetic and molecular analyses have demonstrated that these regions are essential for genome...

Keyword:

heterochromatin, Yeast, epigenetics, and RNAi

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Christina Lawrence

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/20/2018

Date Modified:

09/20/2018

Date Created:

2008-12-05

Resource Type:

Dissertation
Improving Biological Properties of Spherical Nucleic Acids Through Structural Control

Description:

Nucleic acid therapeutics can be drug molecules with high programmability, minimal off-target effects, and the capability to address “undruggable” targets for diseases. In addition, each time a new drug is needed, one needs to only change the sequence as opposed to finding an entirely new structure. One nucleic acid type...

Keyword:

RNAi, siRNA, gene therapy, structure-function, spherical nucleic acid, and nanoparticle

Subject:

Nanotechnology, Pharmaceutical sciences, and Biomedical engineering

Creator:

Vasher, Matthew Kuo

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_938909 and http://dissertations.umi.com/northwestern:16319

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