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Caspase cleavage of HER-2/neu Releases a BH3-like Cell Death Effector

Description:

Breast cancer cells acquire many genetic alterations in apoptotic signaling pathways rendering them resistant to apoptosis. Human Epidermal growth factor Receptor-2 (HER-2/ErbB2/neu) is amplified or overexpressed in approximately 30% of breast and ovarian tumors and correlates with poor prognosis. Although HER-2 is an orphan receptor, it forms potent signaling heterodimers...

Keyword:

HER-2/neu, apoptosis, BH3, caspase substrates, and breast cancer

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Anne Marie Strohecker

Owner:

Scholarly Digital Publishing

Date Uploaded:

07/30/2018

Date Modified:

07/30/2018

Date Created:

05-15-2007

Resource Type:

Dissertation
The modulation of MFG-E8 mediated microglial phagocytosis

Description:

Phagocytosis is an essential mechanism for clearance of pathogens, dying cells, and other unwanted debris in order to maintain tissue health in the body. Macrophages execute this process in the peripheral immune system, but in the brain microglia act as resident macrophages to accomplish this function. In the peripheral immune...

Keyword:

MFG-E8, phagocytosis, apoptosis, Gas6, Alzheimer's disease, and microglia

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Abby Denise Fuller

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/14/2018

Date Modified:

09/14/2018

Date Created:

2008-08-11

Resource Type:

Dissertation

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Caspase cleavage of HER-2/neu Releases a BH3-like Cell Death Effector

The modulation of MFG-E8 mediated microglial phagocytosis

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