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Improving and engineering cell-free systems for glycoprotein production

Description:

The need to rapidly develop and produce life-saving vaccines and therapeutics is critical for overcoming pandemics in a global economy. Recent advances in automation and cell-free systems have opened new avenues for expediting optimization and production of biologic vaccines and therapeutics. A key consideration for the development of protein biologics...

Keyword:

biotechnology, bioproduction, glycosylation, vaccines, cell-free protein synthesis, and synthetic biology

Subject:

Chemical engineering

Creator:

Hershewe, Jasmine Marie

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_780613 and http://dissertations.umi.com/northwestern:15396
Cell-free Technologies for On-demand Glycoprotein Biomanufacturing and Hands-on Biology Education

Description:

Since their introduction nearly a century ago, protein vaccines and therapeutics have revolutionized our ability to prevent and treat human disease. However, existing production processes for biopharmaceuticals are technically complex and rely on living cells, which necessitates highly centralized manufacturing in large-scale production facilities, specialized equipment, and cold-chain distribution. With...

Keyword:

glycoprotein therapeutics, cell-free protein synthesis, decentralized biomanufacturing, synthetic biology, STEM education, and conjugate vaccines

Subject:

Chemical engineering

Creator:

Stark, Jessica C

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Modified:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_686044 and http://dissertations.umi.com/northwestern:14826

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Improving and engineering cell-free systems for glycoprotein production

Cell-free Technologies for On-demand Glycoprotein Biomanufacturing and Hands-on Biology Education

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