Recent discoveries in vitamin D research indicate that vitamin D is a necessary component to several organs and tissues that extends beyond bone formation Furthermore, recent research indicates that vitamin D deficiency is rampant across the globe. Historically, anthropological research has focused on the adaptive significance of skin color to...
Histone methylation plays an important role as an epigenetic regulator, capable of driving stable, persistent changes in gene expression without changing a cell's genetic code. Previous work has used stable isotope labeling (SILAC) in combination with mass spectrometry to observe the relationship between the methylation of two neighboring lysine sites...
NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL). Cells harboring this mutation can become the predominant clone in relapsing disease. We studied the effects of this mutant enzyme...