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Mechanism of Nuclear Import of a Smooth Muscle Cell-Specific Plasmid Vector for Gene Therapy

Description:

Cardiovascular disease is a leading cause of morbidity and mortality worldwide. While many therapies have been used to treat vascular disease symptomatically, gene therapy offers a means of treating the molecular dysfunctions driving disease pathogenesis. Unfortunately, gene therapy has achieved only modest therapeutic success in clinical trials due to a...

Keyword:

nuclear import, karyopherins, plasmid, nuclear localization signal, and gene therapy

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Aaron Michael Miller

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/17/2018

Date Modified:

09/17/2018

Date Created:

2008-08-01

Resource Type:

Dissertation
Development of Alveolar Epithelial Type II Cell-Specific Nuclear Targeting Vectors for Gene Therapy

Description:

Although non-viral gene therapy has great potential for use in the lung, several problems including inefficient gene transfer and expression and the relative lack of cell-specific targeting have limited its applications. The two approaches that have been used to target genes to desired cell types are through specific ligand-receptor interactions...

Keyword:

nuclear import, SP-C, gene therapy, plasmid, and non-viral

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

James Vincent DeGiulio

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/16/2018

Date Modified:

08/16/2018

Date Created:

2007-09-24

Resource Type:

Dissertation

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Mechanism of Nuclear Import of a Smooth Muscle Cell-Specific Plasmid Vector for Gene Therapy

Development of Alveolar Epithelial Type II Cell-Specific Nuclear Targeting Vectors for Gene Therapy

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