Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Pediatric high-grade gliomas (pHGGs) are aggressive pediatric CNS tumors and an important subset are characterized by mutations in H3F3A, the gene that encodes Histone H3.3 (H3.3). Substitution of Glycine at position 34 of H3.3 with either Arginine or Valine (H3.3G34R/V), was recently described and characterized in a large cohort...
Keyword:: genetics, G34R, cancer, ATRX, glioma, and AVB500
Subject:: Molecular biology, Biology, and Biochemistry
Creator:: Abdallah, Aalaa Sanad
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 05/31/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16475 and etdadmin_upload_978815

Description:: Heart failure due to genetic cardiomyopathy is associated with a range of phenotypic expression. The studies in this body of work interrogated the role of noncoding variation in modifying cardiomyopathy phenotypes. We used cap analysis of gene expression in heathy and failed left ventricles to define the regulatory environment of...
Keyword:: noncoding, genetics, MYH7, heart failure, modifier, and enhancer
Subject:: Molecular biology, Genetics, and Biochemistry
Creator:: Gacita, Anthony Martin
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_756135 and http://dissertations.umi.com/northwestern:15193

Description:: Individuals within a species vary in complex phenotypes, such as responses to toxins. This drug-response variation causes patients who are treated with the same medicine to experience a range of side effects, ultimately decreasing the efficacy of some drugs. Particular genetic variants among individuals might contribute to differential drug responses,...
Keyword:: genetics, bleomycin, linkage mapping, natural variation, drug response, and C. elegans
Subject:: Biology
Creator:: Brady, Shannon Colleen
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14708 and etdadmin_upload_667842

Description:: After nearly 100 years of research, the function of sleep is unknown, prompting the desire to examine its regulation in a simpler model organism. In 2000, <em>Drosophila</em> was described as a novel model system to investigate sleep. These early studies defined features of normal sleep in <em>Drosophila</em>, and presented evidence...
Keyword:: genetics, sleep, mushroom bodies, Clock, neuroanatomy, and Drosophila
Subject:: Neuroscience Institute Graduate Program
Creator:: Jena Pitman
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/16/2018
Date Modified:: 08/16/2018
Date Created:: 2007-08-15
Resource Type:: Dissertation

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