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The mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Description:

The NLRP3 inflammasome is a multi-protein complex that drives sterile and pathogen-dependent inflammation. Activation of the NLRP3 inflammasome occurs in two steps: priming and activation. Priming occurs in response to an inflammatory stimulus, such as LPS. LPS-primed macrophages are subsequently activated by a second stimuli, most of which require K+...

Keyword:

macrophage, mitochondria, immunometabolism, inflammasome, and metabolism

Subject:

Biology

Creator:

Billingham, Leah Katherine

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15953 and etdadmin_upload_882213
Functional characterization of MnSOD and ACSS1 acetylation in metabolism and carcinogenesis

Description:

One of the fundamental observations in oncology is that the rate of cancer malignancy increases with age, which applies to most human malignancies including breast cancer. Therefore, it is crucial to elucidate the mechanistic connection between aging and carcinogenesis. The NAD+-dependent sirtuin family, specifically SIRT3, the primary mitochondrial deacetylase, which...

Keyword:

MnSOD, mitochondria, Sirtuin, cancer, ACSS1, and metabolism

Subject:

Biology

Creator:

Gao, Yucheng

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/28/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15526 and etdadmin_upload_815100

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The mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Functional characterization of MnSOD and ACSS1 acetylation in metabolism and carcinogenesis

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