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Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

Description:

Early-life seizures increase susceptibility to seizures in adulthood. However, mechanisms by which seizures in the developing brain lead to increased vulnerability to seizures and exacerbation of neurological injury in adulthood remain unknown. We test the hypothesis that upregulation of proinflammatory cytokine levels and chronic glial activation following early-life seizures result...

Keyword:

seizures, cytokines, microglia, glia, glutamate, and neuroinflammation

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Kathleen Cua Somera-Molina

Owner:

Scholarly Digital Publishing

Date Uploaded:

08/27/2018

Date Modified:

08/27/2018

Date Created:

2007-12-07

Resource Type:

Dissertation
The modulation of MFG-E8 mediated microglial phagocytosis

Description:

Phagocytosis is an essential mechanism for clearance of pathogens, dying cells, and other unwanted debris in order to maintain tissue health in the body. Macrophages execute this process in the peripheral immune system, but in the brain microglia act as resident macrophages to accomplish this function. In the peripheral immune...

Keyword:

MFG-E8, phagocytosis, apoptosis, Gas6, Alzheimer's disease, and microglia

Subject:

Integrated Graduate Program in the Life Sciences

Creator:

Abby Denise Fuller

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/14/2018

Date Modified:

09/14/2018

Date Created:

2008-08-11

Resource Type:

Dissertation

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Glial activation links early-life seizures and increased susceptibility to seizures in adulthood</

The modulation of MFG-E8 mediated microglial phagocytosis

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