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The Role of TACC3 in Regulating Microtubule Dynamics During Herpesvirus Infections

Description:

The microtubule (MT) network and associated regulatory proteins play a critical role during viral infection from facilitating viral particle transport towards the nucleus upon entry to later mediating virion assembly and egress. Many of the precise mechanisms by which viruses commandeer the host MT network to propagate infection remain poorly...

Keyword:

TACC3, virus, microtubules, and +TIP

Subject:

Virology, Microbiology, and Cellular biology

Creator:

Furey, Colleen Patricia

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_856328 and http://dissertations.umi.com/northwestern:15823
Uncovering Molecular Mechanisms of C9orf72- and NEK1-related ALS Pathogenesis Using iPSC-Derived Motor Neurons

Description:

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by motor neuron (MN) degeneration and resulting in progressive paralysis and death. ALS is genetically heterogeneous, disease pathophysiology is not completely understood, and there are no effective drug therapies. To develop broadly applicable therapeutics, we examine disease mechanisms in the...

Keyword:

ALS, C9orf72, iPSCs, nucleocytoplasmic transport, NEK1, and microtubules

Subject:

Molecular biology, Cellular biology, and Neurosciences

Creator:

Daley, Elizabeth

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15607 and etdadmin_upload_825395

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The Role of TACC3 in Regulating Microtubule Dynamics During Herpesvirus Infections

Uncovering Molecular Mechanisms of C9orf72- and NEK1-related ALS Pathogenesis Using iPSC-Derived Motor Neurons

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