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Improving Biological Properties of Spherical Nucleic Acids Through Structural Control

Description:

Nucleic acid therapeutics can be drug molecules with high programmability, minimal off-target effects, and the capability to address “undruggable” targets for diseases. In addition, each time a new drug is needed, one needs to only change the sequence as opposed to finding an entirely new structure. One nucleic acid type...

Keyword:

RNAi, siRNA, gene therapy, structure-function, spherical nucleic acid, and nanoparticle

Subject:

Nanotechnology, Pharmaceutical sciences, and Biomedical engineering

Creator:

Vasher, Matthew Kuo

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_938909 and http://dissertations.umi.com/northwestern:16319
Synthetic and Analytical Techniques to Break Symmetry and Control Structure in Crystals Engineered with DNA

Description:

When attached to another species (e.g. a nanoparticle), the sequence specificity of DNA can be repurposed to program interactions between such entities and to direct their formation into ordered structures. The research presented in this thesis aims to push the boundaries of structures that can be made via this approach....

Keyword:

image analysis, nanoparticle, DNA, symmetry breaking, high-throughput, and crystal engineering

Subject:

Nanotechnology, Chemistry, and Chemical engineering

Creator:

Laramy, Christine

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_617692 and http://dissertations.umi.com/northwestern:14404

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Improving Biological Properties of Spherical Nucleic Acids Through Structural Control

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