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Filtering by: Keyword neurodegeneration Resource type Dissertation

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Identifying Molecular Pathways Linking Circadian Rhythms and Neurodegeneration

Description:

Neurodegenerative diseases (NDs) commonly involve the accumulation and aggregation of neurotoxic proteins that impair and ultimately destroy specific neurons. Considerable evidence from human and animal studies indicates that many NDs show disrupted circadian and sleep as symptoms. Yet little is known about the molecular mechanisms by which genes cause NDs...

Keyword:

genetic screen, neurodegeneration, Huntington’s disease, and circadian

Subject:

Biology and Neurosciences

Creator:

Xu, Fangke

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/12/2020

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:14655 and etdadmin_upload_662687
Alterations of electrical properties in the adult motoneurons in the mSOD1 mouse model of Amyotrophic Lateral Sclerosis

Description:

In Amyotrophic Lateral Sclerosis (ALS), spinal motoneurons degenerate in the order of large motoneurons that innervate fast and fatigable muscle fibers to small motoneurons that innervate slow muscle fibers (Pun et al. 2006). This order of degeneration is peculiar in that it is in direct opposition to the normal order...

Keyword:

motoneurons, persistent inward currents, animal model, neurodegeneration, Amyotrophic lateral sclerosis, and electrophysiology

Subject:

Interdepartmental Neuroscience Program (NUIN)

Creator:

Seoan Huh

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/16/2018

Date Modified:

04/16/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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Identifying Molecular Pathways Linking Circadian Rhythms and Neurodegeneration

Alterations of electrical properties in the adult motoneurons in the mSOD1 mouse model of Amyotrophic Lateral Sclerosis

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