Peripheral neuropathic pain is a debilitating affliction for which there is little effective treatment. Patients suffer from symptoms ranging from loss of sensation to hyperalgesia and allodynia. The neuroinflammatory process in chronic pain conditions has become a main focus of study because of the release of proinflammatory cytokines, which can...
Early-life seizures increase susceptibility to seizures in adulthood. However, mechanisms by which seizures in the developing brain lead to increased vulnerability to seizures and exacerbation of neurological injury in adulthood remain unknown. We test the hypothesis that upregulation of proinflammatory cytokine levels and chronic glial activation following early-life seizures result...
There is increasing evidence that links chronic activation of glial cells and the subsequent self-propagating cycle of neuroinflammation to the neurodegenerative progression of Alzheimer's disease (AD). Nevertheless, attempts to identify currently approved drugs capable of safely attenuating the neuroinflammatory processes in AD have proven disappointing to date, and the development...