Leptin, a peptide mainly secreted in proportion to adipose tissue mass, increases energy expenditure with a parallel increase in breathing. The existence of a leptin-mediated neural circuit linking breathing to metabolism has been speculated, yet the precise central mechanisms were unknown. In my thesis, I show that optogenetic activation of...
Obesity is a multifactorial disease reflecting the interplay of biological and social factors. Lower socioeconomic status (SES), food insecurity, and poor sleep quality are risks factors for obesity; yet, our understanding of the physiological mechanisms behind overweightness is limited. Leptin, a hormone which modulates hunger, could be a potential mechanism...