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Dynamic Mechanisms of Metabotropic Glutamate Receptor Activation and Modulation

Description:

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in humans and play a role in nearly all physiological processes. Among GPCRs, metabotropic glutamate receptors (mGluRs) are a structurally distinct family of synaptic receptors that are essential in regulating neurotransmission and synaptic plasticity. Due to their important regulatory...

Keyword:

structural dynamics, mGluRs, conformational dynamics, membrane proteins, smFRET, and GPCRs

Subject:

Pharmacology, Biochemistry, and Biophysics

Creator:

Liauw, Brandon Wey-Hung

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_937523 and http://dissertations.umi.com/northwestern:16310
The Mechanism of Activation and Sensitivity-Tuning of the Calcium-Sensing Receptor

Description:

Transfer of information across membranes is fundamental to the function of all organisms and is primarily initiated by transmembrane receptors. This is an allosteric process and involves conformational coupling between ligand-binding domain and signaling domain of a receptor. This allosteric mechanism of activation is unclear for many receptors. Moreover, for...

Keyword:

GPCR, CaSR, and smFRET

Subject:

Bioinformatics, Biochemistry, and Biophysics

Creator:

Schamber, Michael Robert

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

09/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:16268 and etdadmin_upload_929368

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Dynamic Mechanisms of Metabotropic Glutamate Receptor Activation and Modulation

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