Animals must establish the correct form during development. Regeneration is a process by which some animals reestablish their form following injury. This process requires both the generation of new missing cells after injury, and information to pattern new cells to reestablish the correct form. Planarian flatworms have an almost unlimited...
Allergic diseases, including asthma, atopic dermatitis, and food allergy, are a widespread health issue. The prevalence of these diseases has been increasing, but the mechanism behind this increase and how allergies develop is not well understood. Although the immune system is central to the pathology of allergy, recent work has...
Spinal cord injury causes devastating and frequently irreversible loss of neurological function. Although injured central nervous system neurons have the intrinsic ability to regenerate, the environment in the damaged spinal cord is non-permissive. The goal of this thesis was to explore the cellular and molecular mechanisms that limit recovery after...