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Mapping out the pathways for spherical nucleic acid biodistribution

Description:

Oligonucleotides can be used to modulate the regulation of pathological genes that are associated with various diseases. However, due to biological barriers, efficient delivery of oligonucleotides, especially to extrahepatic tissues, remains a challenge. To overcome these barriers, multiple delivery strategies have been developed, ranging from medicinal chemistry to nanotechnology. Nanoparticle-based...

Keyword:

surface modification, biodistribution, and spherical nucleic acids

Subject:

Chemistry

Creator:

Zhang, Wuliang

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_830130 and http://dissertations.umi.com/northwestern:15627
Surface Modification with Antifouling Polymers Composed of Polypeptoids and Mussel Adhesive-Inspired Peptides

Description:

Biological fouling of surfaces is problematic for many medical applications because proteins, cells and bacteria can impair the function of devices and lead to catastrophic complications. Numerous strategies exist for reducing fouling in physiological environments; the strategy described in this thesis focuses on the modification of substrates with poly-N-substituted glycine...

Keyword:

nonfouling, polypeptoids, surface modification, Antifouling, mussel adhesive proteins, and surface characterization

Subject:

Biomedical Engineering

Creator:

Andrea Ruth Statz

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/08/2018

Date Modified:

09/08/2018

Date Created:

2008-05-05

Resource Type:

Dissertation

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Mapping out the pathways for spherical nucleic acid biodistribution

Surface Modification with Antifouling Polymers Composed of Polypeptoids and Mussel Adhesive-Inspired Peptides

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