Oligonucleotides can be used to modulate the regulation of pathological genes that are associated with various diseases. However, due to biological barriers, efficient delivery of oligonucleotides, especially to extrahepatic tissues, remains a challenge. To overcome these barriers, multiple delivery strategies have been developed, ranging from medicinal chemistry to nanotechnology. Nanoparticle-based...
Biological fouling of surfaces is problematic for many medical applications because proteins, cells and bacteria can impair the function of devices and lead to catastrophic complications. Numerous strategies exist for reducing fouling in physiological environments; the strategy described in this thesis focuses on the modification of substrates with poly-N-substituted glycine...