Index Catalog // Arch : Northwestern University Institutional Repository

Description:: This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
Keyword:: protein design, cell-penetrating protein, protein folding stability, and synthetic biology
Subject:: Biology, Cellular biology, and Biophysics
Creator:: Kim, Tae-Eun
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_1008136 and http://dissertations.umi.com/northwestern:16683

Description:: This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
Keyword:: protein design, cell-penetrating protein, synthetic biology, and protein folding stability
Subject:: Biology, Cellular biology, and Biophysics
Creator:: Kim, Tae-Eun
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 08/23/2023
Date Created:: 2023-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16695 and etdadmin_upload_1009800

Description:: The need to rapidly develop and produce life-saving vaccines and therapeutics is critical for overcoming pandemics in a global economy. Recent advances in automation and cell-free systems have opened new avenues for expediting optimization and production of biologic vaccines and therapeutics. A key consideration for the development of protein biologics...
Keyword:: biotechnology, bioproduction, glycosylation, vaccines, cell-free protein synthesis, and synthetic biology
Subject:: Chemical engineering
Creator:: Hershewe, Jasmine Marie
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_780613 and http://dissertations.umi.com/northwestern:15396

Description:: Metabolic engineering of microorganisms to produce useful compounds from renewable substrates is a promising means for sustainable, on-demand production of chemicals. However, efforts to design and engineer microbial cell factories are constrained by costly and slow “build” times in which each genetic variation requires re-engineering a new strain for each...
Keyword:: metabolic engineering, cell-free, synthetic biology, prototyping, and limonene
Subject:: Chemical and Biological Engineering
Creator:: Quentin Merle Dudley
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/25/2019
Date Modified:: 01/30/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Description:: There is a need for alternative biomanufacturing solutions to produce novel medicines and help solve long-standing issues regarding difficult-to-treat diseases. Cell-free protein synthesis (CFPS) provides scientists with a new paradigm for producing proteins with an unprecedented freedom and control over the biomolecular machinery involved. In this document, I describe my...
Keyword:: antibodies, genome engineering, non-canonical amino acid, synthetic biology, and Cell-free protein synthesis
Subject:: Chemical and Biological Engineering
Creator:: Rey William Martin
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/21/2018
Date Modified:: 10/21/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

Description:: A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de novo design – allowing...
Keyword:: transcription, RNA, RNA engineering, synthetic biology, and gene regulation
Subject:: Synthetic Biology and RNA engineering
Creator:: Matthew Verosloff, Alexandra Westbrook, James Chappell, and Julius B. Lucks
Owner:: Julius Beau Lucks
Publisher:: MacMillan Publishers
Language:: English
Date Uploaded:: 08/03/2017
Date Modified:: 01/07/2020
Date Created:: 2017-08-03
Resource Type:: Dataset
Alternate Identifier:: doi:10.21985/N28S9B

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