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Description:: The polymerization of the microtubule-associated protein, tau, into insoluble filaments is common to Alzheimer's disease (AD) and in a variety of dementias. The conformational change required for tau to transition from soluble monomers to filamentous AD pathology involves the extreme N-terminus of tau coming into contact with other regions of...
Keyword:: Alzheimer's disease, tangle, N-terminus, frontotemporal dementia, and tau
Subject:: Neuroscience Institute Graduate Program
Creator:: Peleg Moshe Horowitz
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/07/2018
Date Modified:: 05/07/2018
Date Created:: 2006-11-16
Resource Type:: Dissertation

Description:: Neurofibrillary tangle (NFT) formation in Alzheimer's disease (AD) and tauopathies occurs when tau protein adopts secondary structure and self-aggregates within neurons. Accompanying NFT maturation are post-translational modifications to tau; hyperphosphorylation, truncation and conformational changes occur in a highly sequential manner. In contrast, granulovacuolar degeneration bodies (GVDs) are a second type...
Keyword:: granules, p-SAPK/JNK, tau, and tangles
Subject:: Neuroscience Institute Graduate Program
Creator:: Sarita Lagalwar
Owner:: Scholarly Digital Publishing
Date Uploaded:: 05/14/2018
Date Modified:: 05/14/2018
Date Created:: 2007-02-19
Resource Type:: Dissertation

Description:: In several neurodegenerative diseases, the microtubule-associated protein tau self-aggregates to form filaments that accumulate in neurons and/or glia, although the relationship between tau aggregation and cell death is a subject of debate. The amino terminus of tau is involved in conformational changes that appear critical for filament formation, hinting at...
Keyword:: filament, axonal transport, kinesin, Alzheimer's disease, and tau
Subject:: Neuroscience Institute Graduate Program
Creator:: Nichole LaPointe
Owner:: Scholarly Digital Publishing
Date Uploaded:: 09/06/2018
Date Modified:: 09/06/2018
Date Created:: 2008-02-21
Resource Type:: Dissertation

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