Mammalian transcriptional regulation is well-known to be complex and highly context dependent. Different genetic and epigenetic features, including single nucleotide polymorphisms (SNPs) that function as cis- or trans-expression quantitative trait loci (eQTLs), transcription factor (TF) interaction profile with cis-regulatory elements (CREs), methylation of CpG dinucleotide sequences, and histone modification that...
Molecular-oriented single-site heterogeneous catalysis is a powerful approach to address the long-lasting challenge of the structure-activity relationship in catalysis, as it allows molecular level control of the catalytic centers and thus the elucidation of reaction mechanisms. In this dissertation, single-site molybdenum-dioxo species have been immobilized on carbon supports, i.e. activated...
I present the body of work I have pursued over the course of my doctoral study at Northwestern University. First, I conduct an analysis of the measurement abilities of distinctive LISA detector designs, examining the influence of LISA's low-frequency performance on the detection and characterization of massive black hole binaries....
In nearly all Eukaryotes, the membrane-enclosed nucleus contains the vast majority of the cellular genome. Within this sub-cellular compartment, the nuclear architecture facilitates genomic chromatin organization. Controlling chromosomal loci’s spatial positioning relative to subnuclear structures and each other can have local and global effects on gene expression. Moreover, chromatin organization...
Competitive gaming, or esports, is a high-skill endeavor embedded in a highly gendered social context. Using multiple methodological approaches, this dissertation argues that gender-gaming inequality is a result of changeable stereotypes that impact women throughout their lives. Specifically, gender-gaming stereotypes limit women’s initial access to gaming, discourage their continued interest...
We use Goerss-Hopkins theory to show that if E is a p-local Landweber exact homology theory of height n and p > n^2 + n + 1, then there exists an equivalence hSpE ≃ hD(E∗E) between homotopy categories of E-local spectra and differential E∗E-comodules, generalizing Bousfield’s and Franke’s results to...
This dissertation contains two topics. The first topic focuses on how to use information design to minimize costs of implementing a policy that guarantees 100% passing rate of all participants by providing enough compensation for the their effort. The second topic explores an auction setting which involves financially distressed business...
The answer to the question “Why do we sleep?” lies in understanding the biological underpinnings of homeostatic drive to sleep. Wakefulness is correlated with numerous changes in brain activity, structure and gene/protein expression that re-normalize following sleep however which of these elements is sufficient to cause sleep drive and how...
Skeletal muscle is a highly sexually dimorphic tissue, with males and females exhibiting differences in muscle size, gene transcription, and metabolism. This thesis describes two models wherein males and females responded to an intervention with the same physiological adaptation but through two distinct mechanisms. In the first model, mice of...
Unlike other products or services, electricity cannot be easily stored, and its delivery cannot be delayed by keeping customers in queues. The electricity supply has to be instantly available to serve a continuously varying demand. Traditionally, electric utilities would match their supply to the demand by adjusting the production output...
Fluorescence microscopy has become a widely used tool in many research areas. However, its spatial resolution, limited to 250 nm by the diffraction limit of light, has restricted direct observation of details of ultrastructural biology. In recent years, spectroscopic single-molecule localization microscopy (sSMLM), one of super-resolution imaging techniques, has been...
Rising social inequality across economic, gender, and racial lines is a pressing issue of our time. Despite widespread agreement that inequality exists, there are stark ideological disagreements about its extent, its victims, and about what – if anything – should be done to address it. Prior work demonstrates that the...
Robots can be capable partners when interacting with humans, but their value is largely dependent on how information is communicated in that partnership. In physical human-robot interaction, information is communicated via motion---configurations, velocities, forces, and torques. The autonomy interprets these implicit signals using metrics, which ultimately drive the the autonomy....
Seasonal malaria chemoprevention (SMC) was first recommended by the World Health Organization (WHO) in 2012 to prevent uncomplicated malaria in children and began implementation in Burkina Faso in 2014 under programmatic campaigns. Systematic assessment of the impact of national SMC campaigns requires data with weekly or monthly temporal resolution over...
The need to rapidly develop and produce life-saving vaccines and therapeutics is critical for overcoming pandemics in a global economy. Recent advances in automation and cell-free systems have opened new avenues for expediting optimization and production of biologic vaccines and therapeutics. A key consideration for the development of protein biologics...
Over the past decade, wearables have become pervasive in our lives. Healthcare wearables like a smartwatch continuously monitor personal health status and provide personalized feedback to motivate progress towards medically recommended goals. While present set of on-body electronics empowers users to visualize health status outside of clinic spaces, its traditionally...
In the Nicomachean Ethics and Politics, I find that Aristotle endorses two distinct forms of political activity. The first form, which I term statesman activity, is intrinsically valuable. Aristotle thinks that we should value this kind of political activity because it is constitutive of human well-being. The second form, which...
Integrating the selective reconstruction of the past with an imagined future, narrative identity is a person’s internalized and evolving story of the self, functioning to provide life with some degree of meaning, purpose, and temporal coherence (McAdams & McLean, 2013). Moreover, narrative identity has been found to be associated with...
ABSTRACT This dissertation moves work on school discipline into the digital era by filling a gap in the literature which has largely ignored how data from digital student ecosystems are mined and processed by school authority. My dissertation interrogates the role youth of youth online behavior in school discipline decision-making....
Pseudomonas aeruginosa is an important gram-negative opportunistic pathogen whose large genome allows it to thrive in diverse environments. There is a wide range of phenotypic variation within the species, which can be attributed both to variation in sequences present in most isolates (the core genome) or the presence or absence...