Pollution-intensive industrial manufacturing processes threaten the health of ecosystems and societies through toxic waste streams and energy intensive processes that lead to greenhouse gas emissions. Biological systems present more sustainable routes to many useful industrial chemicals by using enzymes at low temperatures, but the time and effort required to optimized...
This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
Temperature affects all biological processes, from the rate of cellular growth and metabolism to the stability of proteins that make up the machinery of life itself. Thus, all organisms must have the capacity to detect and respond to external temperature. Thermosensation endows animals with the ability to sense and respond...
This dissertation presents novel advancements in the field of continuous nonlinear optimization, focusing on the development of efficient second-order methods for second-order conic programs (SOCPs) and continuous nonlinear two-stage optimization problems. The primary focus is on the theory and computations of Sequential Quadratic Programming (SQP) methods, which are widely used...
Herein, we present an overview of our studies of the morphology, dynamics, and formation of heterogeneous soft matter systems via the emerging technique of liquid phase transmission electron microscopy (LPTEM). This particular subset of materials, more commonly referred to as emulsions, is tremendously commercially and biologically relevant, encompassing applications in...
This dissertation explores the entanglements of performed refusals and witnessing practices in the face of gendered violences. I analyze how contemporary artists use staged performance to generate new modes for witnessing histories of gendered violence across temporal and national boundaries. In particular, I investigate four performances addressing local histories of...
Bacteria represent the most abundant form of life on Earth and have evolved to successfully colonize nearly every environmental niche. In doing so, bacteria predominately form multicellular communities known as biofilms, resulting in increased resilience, persistence, and emergent behaviors. Consequently, biofilms present an attractive target for engineering and synthetic biology,...
The literature on racial/ethnic diversity in schools largely shows evidence of positive academic outcomes for students in diverse schools relative to segregated schools. At the same time, there is ample research demonstrating the discrimination and marginalization that students of color experience in desegregated schools. In this dissertation, I seek to...
Visual information plays a critical role in controlling movement. People use visual information to plan future actions and correct current actions through feedforward and feedback processes, respectively. We can gain insights into these visually guided motor control processes by quantifying where people look during movement and measuring how much they...
Historians have long argued that humanitarianism—what Thomas Haskell once described as “alleviating the suffering of distant strangers”—first emerged in eighteenth-century Europe as part of a complex set of perceptual changes involving capitalist growth, Enlightenment ideas, and Christian values. Given these claims, it is no coincidence that humanitarianism has often been...