Genetic studies have found variants in the protein-degrading autophagy-lysosomal pathway (ALP) to be among the most common risk factors for developing Parkinson’s disease (PD). Macroautophagy (MA) is the arm of this pathway which delivers cytosolic components to lysosomes for degradation and is essential for neuronal health. The defining pathological protein...
This dissertation explores Holocene climate change along the west coast of Greenland and late Holocene climate variability in the subpolar North Atlantic region using paleolimnology. Lake sediment archives and the climate proxies contained within them provide a valuable window into past temperature change on Greenland, home to one of Earth’s...
Previous studies have documented a systematic discrepancy between probabilistic seismic hazard maps and historical records of shaking (Stein et al., 2015; Brooks et al., 2016, 2017, 2018, 2019; Salditch et al., 2020; Salditch, 2021). In almost every case, shaking predicted by the hazard map is higher than that historically observed....
Objective: To evaluate patient-reported experiences of telehealth and disparities in access, use, and satisfaction with telehealth visits during the COVID-19 pandemic (aim 1), to evaluate prevalence of portal use pre-, peri-, and post-pandemic, among the C3 cohort, and investigate any disparities in use by sociodemographic factors (aim 2), and to...
Phonotactic patterns are generalizations that govern the order of consonants and vowels, within words and syllables. Certain second-order phonotactic patterns—those that relate multiple sounds within a syllable, such as “if the vowel is [ɪ], then [s] can only appear at the end of the syllable”—require a period of sleep-based consolidation...
Protein-protein interactions are ubiquitous in living systems, and mediate important cellular processes from decision making to immunity against pathogens. Furthermore, protein-protein interactions are key to many protein therapeutics, pathogen diagnostics, and numerous synthetic biology applications. As a result, there has been significant effort to develop methods to express potential protein...
Metal-organic frameworks are crystalline, nanoporous materials formed by metal nodes connected by organic ligands. MOFs represent an exciting approach to materials design where a material with desired properties can be made by choosing the compatible nodes, linkers and topologies independently. MOFs are highly porous and have high surface areas...
Policies supporting families with young children provide an important context for human development. The two primary public policies available to caregivers around and after childbirth are parental leave and early care and education (ECE). A substantial body of research evaluates the effects of parental leave and ECE policies on various...
In this dissertation, I provide insight into different aspects of the law and politics of trade secrecy at four levels of analysis. Part I examines trade secrecy from an international and comparative perspective. It encompasses Chapters 2 and 3 and focuses on (#1) international law and (#2) comparative national policy....
This dissertation describes three studies which develop a deeper understanding of both failure and performance in human service referral networks focusing on veterans. It draws on theories across network science, public administration, organizational communication, and technology design to explore three major questions: 1) how stakeholders in veteran care networks define...