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Filtering by: Resource type Dataset Subject Synthetic Biology

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Computational design of Small Transcription Activating RNAs (STARs) for versatile and dynamic gene regulation

Description:

A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de novo design – allowing...

Keyword:

transcription, RNA, RNA engineering, synthetic biology, and gene regulation

Subject:

Synthetic Biology and RNA engineering

Creator:

Matthew Verosloff, Alexandra Westbrook, James Chappell, and Julius B. Lucks

Owner:

Julius Beau Lucks

Publisher:

MacMillan Publishers

Language:

English

Date Uploaded:

08/03/2017

Date Modified:

01/07/2020

Date Created:

2017-08-03

Resource Type:

Dataset

Alternate Identifier:

doi:10.21985/N28S9B
Source Data for "Point-of-use detection of environmental fluoride via a cell-free riboswitch-based biosensor."

Description:

Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...

Keyword:

Diagnostic, Fluoride, Riboswitch, Cell-Free, and Synthetic Biology

Subject:

Synthetic Biology and Diagnostics

Creator:

Nancy Kelley-Loughnane, Matthew S. Verosloff, Michael C. Jewett, Walter Thavarajah, Julius B. Lucks, and Adam D. Silverman

Contributor:

This work was supported by the Air Force Research Laboratory Center of Excellence for Advanced Bioprogrammable Nanomaterials (C-ABN) Grant FA8650-15-2-5518 (to M.C.J. and J.B.L), the David and Lucile Packard Foundation (to M.C.J.), an NSF CAREER Award (1452441 to J.B.L.), and the Camille Dreyfus Teacher-Scholar Program (to M.C.J. and J.B.L.). A.D.S. was supported in part by the National Institutes of Health Training Grant (T32GM008449) through Northwestern University’s Biotechnology Training Program.

Owner:

Julius Beau Lucks

Language:

English

Date Uploaded:

06/18/2019

Date Modified:

01/08/2020

Date Created:

2019-06-04

Resource Type:

Dataset

Alternate Identifier:

https://doi.org/10.21985/N2RJ64

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Computational design of Small Transcription Activating RNAs (STARs) for versatile and dynamic gene regulation

Source Data for "Point-of-use detection of environmental fluoride via a cell-free riboswitch-based biosensor."

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