Like many diseases, atherosclerotic cardiovascular disease is driven by the activity of inflammatory cells. Using molecular imaging to target and analyze populations of inflammatory cells is one promising strategy to non-invasively assess atherosclerosis progression. However, current molecular imaging contrast agents are not suited for such targeted imaging applications. Nanomaterial-based strategies...
The shoulder is the most mobile joint in the human body, allowing for the execution of complex and athletic tasks. Unfortunately, such expansive mobility comes at a cost. The shoulder is prone to instability, or painful symptoms associated with increased humeral head translation, and dislocation. To prevent dislocations and maintain...
Nanocarriers, structures with at least one dimension on the nanoscale (1-1000 nm), have been engineered for delivery of various cargoes. The shape and flexibility of nanocarriers are important parameters that influence their biological performance. Self-assembling polymeric filamentous nanocarriers, known as filomicelles (FM), are of great interest to nanomedicine due to...
Nanocarriers as structures with at least one dimension in the nanometer scale are capable of loading small molecule therapeutics that would otherwise have poor bioavailability, non- specific uptake, and off target effects. Polymeric nanocarriers can be modified to tune their chemical and biological behavior to better suit the intended application....
