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-
- Description:
- T cells and cancer cells have many common features, including their need to proliferate and their metabolic requirements. In particular, glucose metabolism is highly upregulated in both cancer cells and T cells to support proliferation and other cellular functions. The first step of glycolysis is catalyzed by Hexokinase, which exists...
- Keyword:
- Hexokinase 2 and T Cell
- Subject:
- Cellular biology and Immunology
- Creator:
- Mehta, Manan M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_616623 and http://dissertations.umi.com/northwestern:14398
-
- Description:
- Prostate cancer (PCa) is the most common non-cutaneous cancer among U.S. men. Lack of effective treatments for advanced disease make it a significant public health concern. However, PCa’s long natural history makes it an excellent target for prevention approaches that reduce overtreatment of indolent disease, treatment related morbidity, and mortality....
- Keyword:
- SELECT, Extracellular matrix, Prostate cancer, Reactive Oxygen Species, Organoids, and Fatty Acid Oxidation
- Subject:
- Molecular biology, Biology, and Cellular biology
- Creator:
- Njoroge, Rose Nyawira
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14428 and etdadmin_upload_623433
-
- Description:
- NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL). Cells harboring this mutation can become the predominant clone in relapsing disease. We studied the effects of this mutant enzyme...
- Keyword:
- oncology, acute lymphocytic leukemia, histone post-translational modifications, epigenetics, and cancer genetics
- Subject:
- Molecular biology, Oncology, and Cellular biology
- Creator:
- Swaroop, Alok
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14456 and etdadmin_upload_626665
-
- Description:
- Endothelial cells (ECs) require glycolysis for proliferation and migration during angiogenesis; however, the necessity for the mitochondrial respiratory chain during angiogenesis is not known. In this study, we report that inhibition of respiratory chain complex III impairs proliferation, but not migration of ECs in vitro by decreasing the NAD+/NADH ratio....
- Keyword:
- Angiogenesis and Mitochondria
- Subject:
- Cellular biology
- Creator:
- Diebold, Lauren P
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_622203 and http://dissertations.umi.com/northwestern:14421
-
- Description:
- Glioblastoma (GBM) is a highly malignant brain tumor that accounts for the most commonly diagnosed type of primary brain tumors in adults. It has a poor prognosis of only 15 months from the time of diagnosis. The gold standard therapy regimen consists of radiotherapy and the chemotherapeutic temozolomide. Both of...
- Keyword:
- Isocitrate Dehydrogenase, Glioblastoma, cancer, one-carbon metabolism, metabolism, and cytosolic serine hydroxymethyltransferase
- Subject:
- Cellular biology
- Creator:
- May, Jasmine Louise
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_593360 and http://dissertations.umi.com/northwestern:14231
-
- Description:
- Oocyte meiosis is a specialized, but error prone, form of cell division that is poorly understood. Errors during meiosis often result in aneuploidy, or abnormal chromosome number, that impacts human health and fertility. Aneuploidy is the leading cause of miscarriages and birth defects, such as Down's syndrome in which cells...
- Keyword:
- chromosome segregation, spindle, meiosis, midzone, oocyte, and anaphase
- Subject:
- Molecular biology and Cellular biology
- Creator:
- Heath, Carissa Marie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_663079 and http://dissertations.umi.com/northwestern:14678
-
- Description:
- Type I interferon (IFN) is the primary antiviral cytokine establishing a broad and potent antiviral response to protect mammalian cells from virus infection. The functional repertoire of IFN extends to innate and adaptive immunity, neoplastic transformation, resistance and cancer immunotherapy. IFN functions are primarily mediated through the Janus kinase (JAK)...
- Keyword:
- ISGF3, Interferon, Chromatin, Antiviral, ISG, and H2A.Z
- Subject:
- Virology, Molecular biology, and Cellular biology
- Creator:
- Au Yeung, Weng Si (Nancy)
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_618020 and http://dissertations.umi.com/northwestern:14409
-
- Description:
- The cellular innate immune response to viruses is a defense mechanism executed by most cells in the human body to form the initial barrier to virus replication. Detection of viral nucleic acids initiates widespread gene expression changes that combine to establish an antiviral state and stimulate professional immune cell activation....
- Subject:
- Molecular biology and Cellular biology
- Creator:
- Kasat, Roli Mandhana
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_618029 and http://dissertations.umi.com/northwestern:14410
-
- Description:
- Proper size control of organs and tissues is critical to their function, and it is necessary for the millions of precisely sized tubes that make up those organs— for example, excessive cell growth can lead to devastating diseases such as Polycystic Kidney Disease. The regulation of tube growth is therefore...
- Keyword:
- Trafficking, Non-apoptotic, Trachea, Caspase, and Apoptosis
- Subject:
- Molecular biology, Biology, and Cellular biology
- Creator:
- McSharry, Saoirse Susan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_661142 and http://dissertations.umi.com/northwestern:14599
-
- Description:
- Currently, platelet transfusions, possessing profound clinical importance in the clotting of blood and healing of wounds, are entirely derived from human volunteer donors. This approach is limited by a 5-day shelf life, the potential risk of contamination, and differences in donor/recipient immunology. In vivo, platelets are formed when bone marrow...
- Keyword:
- Applied sciences, Biological sciences, Megakaryocyte, Cell therapies, Computational fluid dynamics, and Microfluidic bioreactor
- Subject:
- Bioengineering, Chemical engineering, and Cellular biology
- Creator:
- Martinez, Andres Felipe
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_657405 and http://dissertations.umi.com/northwestern:14571
-
- Description:
- Inter-organelle contacts facilitate communication between organelles and impact fundamental cellular functions. Investigations into the molecular mechanisms of inter-organelle tethering are still in the early stages, and we are just beginning to appreciate the number and variety of inter-organelle tethers that exist. We have used budding yeast as a model polarized...
- Keyword:
- mitochondria and membrane contact sites
- Subject:
- Biology and Cellular biology
- Creator:
- Kraft, Lauren Michele
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_626904 and http://dissertations.umi.com/northwestern:14460
-
- Description:
- The blueprint of life is contained within the sequence of an organism’s genome. While virtually all cells of an individual multicellular eukaryotic organism contain a near identical code of nucleic acid sequences, an organism must give rise to and maintain a varied set of cells and phenotypes. As such, sequence...
- Keyword:
- Genome, Epidermal Differentiation, Nuclear Organization, and Transcription
- Subject:
- Molecular biology, Genetics, and Cellular biology
- Creator:
- Garza-Gongora, Arturo
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_617313 and http://dissertations.umi.com/northwestern:14401
-
- Description:
- Promyelocytic leukemia (PML) nuclear bodies act as quality control centers in the nucleus, participating in a plethora of nuclear functions. As such, PML bodies are a signature model for functional nuclear organization. PML bodies have a dynamic protein composition that responds to changing conditions of the cell. Many of the...
- Keyword:
- nuclear organization, no-go decay, mRNA surveillence, PML, Ataxin-1, and stress
- Subject:
- Molecular biology and Cellular biology
- Creator:
- Fanslow, Danielle
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_614059 and http://dissertations.umi.com/northwestern:14390
-
- Description:
- Desmosomes, complex structures found at intercellular junctions, are important for the development, structural integrity, and immune barrier of the skin. Extracellular components of the desmosome connect neighboring cells and intracellular interactions amongst cadherin, armadillo, and plakin proteins anchor the desmosome to intermediate filaments. Beyond their canonical role as “spot welds”...
- Subject:
- Health sciences and Cellular biology
- Creator:
- Lee, Sherry
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/28/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_572406 and http://dissertations.umi.com/northwestern:14076
-
- Description:
- Iron is an essential nutrient and is critical for cellular growth and metabolism. Here, we delineate a novel mechanism by which iron alters amino acid homeostasis and mTOR activity by remodeling the cellular epigenetic landscape. We find that iron deficiency inactivates Jumonji-C domain containing histone-demethylases, resulting in histone hyper-methylation and...
- Keyword:
- Iron, Epigenetics, Mitophagy, Metabolism, and mTOR
- Subject:
- Cellular biology
- Creator:
- Shapiro, Jason Solomon
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15209 and etdadmin_upload_759499
-
- Description:
- Although centrosomes nucleate and organize microtubules in mitotically-dividing cells, spindles in female reproductive cells (oocytes) form in their absence. In some organisms acentrosomal spindle assembly is mediated by acentriolar microtubule organizing centers (MTOCs) that are thought to functionally replace centrosomes. However, spindle assembly in human oocytes does not require MTOCs;...
- Keyword:
- acentrosomal, meiosis, acentriolar, kinesin, microtubule, and C. elegans
- Subject:
- Molecular biology, Biochemistry, and Cellular biology
- Creator:
- Wolff, Ian
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_763687 and http://dissertations.umi.com/northwestern:15248
-
- Description:
- Proper partitioning of mitochondria and mtDNA is critical for cellular health. Investigations into mitochondrial inheritance, specifically how mtDNA inheritance is coupled with the inheritance mitochondrial compartment, are still in the early stages. We use budding yeast as a model polarized cell system to study a mitochondrial Myo2-adaptor protein, Mmr1, in...
- Keyword:
- mitochondria, mitochondrial tethering, mtDNA, Mmr1, and mitochondrial inheritance
- Subject:
- Molecular biology, Biochemistry, and Cellular biology
- Creator:
- Chen, WeiTing
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_763646 and http://dissertations.umi.com/northwestern:15245
-
- Description:
- Dysfunction in mitochondrial dynamics is believed to contribute to a host of neurological disorders and has recently been implicated in cancer metastasis. The outer mitochondrial membrane adapter proteins Miro1 and Miro2 play a role in the regulation of mitochondria. Each paralog comprises two GTPase domains flanking two centrally located calcium/magnesium-binding...
- Subject:
- Cellular biology
- Creator:
- Smith, Kyle P
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15631 and etdadmin_upload_831047
-
- Description:
- The opposing activities of phosphatases and kinases determine the phosphorylation status of proteins, yet kinases have received disproportionate attention in studies of cellular processes, with the roles of phosphatases remaining less understood. This dissertation describes the use of self-assembled monolayer laser desorption/ionization mass spectrometry (SAMDI-MS) together with peptide arrays to...
- Keyword:
- SAMDI-MS, Phosphatases, High-Throughput Experiments, Enzyme Specificity, β-Catenin, and Peptide Arrays
- Subject:
- Chemistry, Biochemistry, and Cellular biology
- Creator:
- Huang, Che-Fan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_819016 and http://dissertations.umi.com/northwestern:15570
-
- Description:
- Levels of the several different human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; A3) cytidine deaminases vary across different cell types. While levels of nuclear-localized A3s are low or non-existent in primary cells, a nuclear A3 is often upregulated in cancer cells. Increased chromosomal mutagenesis due to nuclear A3...
- Keyword:
- VHL, HIV, Proteasome, and APOBEC
- Subject:
- Cellular biology
- Creator:
- Scholtes, Gael Kaushik
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_822125 and http://dissertations.umi.com/northwestern:15598
-
- Description:
- When a collection of individual units behave synchronously, it is often useful to describe the actions of the group. Broadly speaking in Physics, individuals are described as particles and collective actions are described using waves. However, the dynamic symphony of life ordains that orchestral sections play in harmony for a...
- Keyword:
- Coherence, Vibrational, Quantum Optics, and Electronic
- Subject:
- Physical chemistry and Cellular biology
- Creator:
- Zhao, Shawn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/06/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_833782 and http://dissertations.umi.com/northwestern:15651
-
- Description:
- Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by motor neuron (MN) degeneration and resulting in progressive paralysis and death. ALS is genetically heterogeneous, disease pathophysiology is not completely understood, and there are no effective drug therapies. To develop broadly applicable therapeutics, we examine disease mechanisms in the...
- Keyword:
- ALS, C9orf72, iPSCs, nucleocytoplasmic transport, NEK1, and microtubules
- Subject:
- Molecular biology, Cellular biology, and Neurosciences
- Creator:
- Daley, Elizabeth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15607 and etdadmin_upload_825395
-
- Description:
- Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...
- Keyword:
- iPSC, Interorganelle contacts, GBA, Lysosome, Mitochondria, and Parkinson's disease
- Subject:
- Molecular biology, Cellular biology, and Neurosciences
- Creator:
- Kim, Soojin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_825288 and http://dissertations.umi.com/northwestern:15606
-
- Description:
- Natural Killer (NK) cell dysfunction is associated with poorer clinical outcome in cancer patients. What regulates NK cell dysfunction in tumor microenvironment is not well understood. NKG2D/NKG2DL pathway is very well recognized as an effective immune axis in tumor immunosurveillance. Abundant evidence from experimental preclinical animal models as well as...
- Subject:
- Biology, Cellular biology, and Immunology
- Creator:
- Dhar, Payal
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15682 and etdadmin_upload_839121
-
- Description:
- The microtubule (MT) network and associated regulatory proteins play a critical role during viral infection from facilitating viral particle transport towards the nucleus upon entry to later mediating virion assembly and egress. Many of the precise mechanisms by which viruses commandeer the host MT network to propagate infection remain poorly...
- Keyword:
- TACC3, virus, microtubules, and +TIP
- Subject:
- Virology, Microbiology, and Cellular biology
- Creator:
- Furey, Colleen Patricia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_856328 and http://dissertations.umi.com/northwestern:15823
-
- Description:
- Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumor immunity. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties, can promote autoimmunity and/or facilitate more effective tumor immunity. A comprehensive understanding...
- Keyword:
- Tumor, Treg, Ubiquitin, Foxp3, Usp21, and Usp22
- Subject:
- Biology, Cellular biology, and Immunology
- Creator:
- Montauti, Elena
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_846345 and http://dissertations.umi.com/northwestern:15780
-
- Description:
- Reproduction requires a complex orchestration of processes from the formation of the reproductive system through the successful development of the fetus, and nutrients are necessary to fuel these processes during many aspects of reproduction. Zinc is an essential metal that is fundamental in gamete maturation, gonadogenesis, and fertilization. Disruption in...
- Keyword:
- Ovulation, Labile zinc, Caenorhabditis elegans, Zinc transporters, Reproductive biology, and Live imaging
- Subject:
- Molecular biology, Genetics, and Cellular biology
- Creator:
- Sue, Aaron Christopher
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_902758 and http://dissertations.umi.com/northwestern:16074
-
- Description:
- Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To...
- Subject:
- Virology, Cellular biology, and Immunology
- Creator:
- Madden, Patrick
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15987 and etdadmin_upload_892041
-
- Description:
- Membrane contact sites (MCSs) facilitate communication and organization of organelles that contribute to fundamental cellular processes. It has become increasingly appreciated how extensive and essential MCSs are for cellular health, and this field is rapidly growing. We use budding yeast as a model system to study the mechanisms of how...
- Keyword:
- Membrane Contact Sites, Organelle Positioning, and Mitochondria
- Subject:
- Cellular biology
- Creator:
- Anderson, Heidi Lynn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_873821 and http://dissertations.umi.com/northwestern:15900
-
- Description:
- Prostate cancer is the most common cause of cancer among men in the United States, and the second most common cause of cancer-related death, accounting for significant morbidity and mortality. This dissertation describes the genomic landscape of prostate cancer from multiple angles to identify mechanisms of disease heterogeneity amongst patients....
- Keyword:
- cellular biology
- Subject:
- Cellular biology
- Creator:
- Chalmers, Zachary R
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Modified:
- 01/06/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15993 and etdadmin_upload_894281
-
- Description:
- RNA viruses cause a wide range of diseases that range from mild respiratory illness to fatal hemorrhagic fevers. To combat these pathogens, most cells in the human body scan the cell for viruses and activate a potent cell-intrinsic immune response by producing interferon (IFN), a cytokine that amplifies the innate...
- Subject:
- Virology, Molecular biology, and Cellular biology
- Creator:
- Lenoir, Jessica
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_866862 and http://dissertations.umi.com/northwestern:15886
-
- Description:
- Preterm birth (PTB) is the leading cause of infant morbidity worldwide. Approximately 380,000 babies are born prematurely in the USA every year. Estrogen (E2) and progesterone (P4) play essential roles during pregnancy and labor; a clear understanding of their action mechanisms, however, is lacking. E2 and P4 function by activating...
- Keyword:
- progesterone receptor, estrogen receptor, labor, genome-wide, ChIP-Seq, and RNA-Seq
- Subject:
- Obstetrics, Cellular biology, and Developmental biology
- Creator:
- Dotts, Ariel Janiece
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_908705 and http://dissertations.umi.com/northwestern:16117
-
- Description:
- Understanding the regulatory programs enabling cancer stem cells (CSCs) to self-renew and drive tumorigenicity could identify new treatments. Through comparative chromatin state and gene expression analyses in CSCs vs. non-CSCs, we identified FOXK2 as a highly expressed stemness-specific transcription factor (TF). Its genetic depletion diminished stemness features and reduced tumor...
- Subject:
- Cellular biology
- Creator:
- Zhang, Yaqi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_925103 and http://dissertations.umi.com/northwestern:16199
-
- Description:
- Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins, desmogleins and desmocollins, are related to the classical cadherins but their cytoplasmic domains are tailored for anchoring intermediate filaments instead of actin to sites of cell-cell adhesion. The...
- Keyword:
- Keratinocyte, Desmosome, Retromer chaperone, Dsg1, SAM syndrome, and Endosomal trafficking
- Subject:
- Cellular biology
- Creator:
- Hegazy, Marihan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_944940 and http://dissertations.umi.com/northwestern:16344
-
- Description:
- Tumor-initiating cells with reprogramming plasticity are thought to be essential for cancer development and metastatic regeneration in many cancers; however, the molecular mechanisms are not fully understood. We have previously identified that CD44, a breast tumor-initiating cell marker, drives mammosphere self-renewal and multicellular aggregation of circulating tumor cell (CTC) clusters,...
- Keyword:
- exosomes, CD44, cancer stem cells, extracellular vesicles, CD81, and breast cancer
- Subject:
- Molecular biology, Biology, and Cellular biology
- Creator:
- Ramos, Erika Kathryn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16152 and etdadmin_upload_916551
-
- Description:
- Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and source of ATP. In contrast, the failing heart favors glucose as a fuel source. A bootstrap analysis for genes with deviant...
- Keyword:
- Heart Failure, Glucose, Cardiomyopathy, Drosophila, Metabolism, and Mitochondria
- Subject:
- Molecular biology, Gender studies, and Cellular biology
- Creator:
- Fischer, Julie Anne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16326 and etdadmin_upload_941216
-
- Description:
- Fat represents an important source of energy for ovarian cancer (OC) cells and is supplied either through import from the tumor milieu or via de novo lipogenesis. During fast tumor growth, when nutrients are scarce, lipogenesis becomes the primary source of fatty acids. Stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in...
- Keyword:
- ER stress, Fatty acids, Ovarian cancer, and Lipid metabolism
- Subject:
- Bioinformatics, Oncology, and Cellular biology
- Creator:
- Zhao, Guangyuan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/16/2023
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_940639 and http://dissertations.umi.com/northwestern:16324
-
- Description:
- Meiosis is a specialized form of cell division that gives rise to haploid reproductive cells by replicating the genetic material once and undergoing two rounds of partitioning. While most forms of cell division require centrosomes to assemble a bipolar microtubule-based spindle that segregates chromosomes, female gametes (oocytes) are unique in...
- Subject:
- Cellular biology
- Creator:
- Horton, Hannah Elizabeth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16528 and etdadmin_upload_984240
-
- Description:
- Neuroblastoma is one of the most common childhood cancers with one of the lowest survival rates, accounting for 15% of childhood cancer mortality. Approximately 15% of patients do not respond to initial treatment, and about half of children treated for high-risk neuroblastoma will relapse following remission. Ionizing radiation has long...
- Subject:
- Cellular biology
- Creator:
- Ritner, Carissa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_977952 and http://dissertations.umi.com/northwestern:16470
-
- Description:
- Biologically active small molecules remain the foundation for the medical management of human disease. Their impacts on human health, longevity, culture, and society are difficultly overstated. In large part, medicines derived from organic compounds are the result of the tireless efforts of chemical practitioners––both past and present––who have dedicated much...
- Keyword:
- Mellpaladine A, Glioblastoma, Autophagy, MAP2K7, and T-ALL
- Subject:
- Organic chemistry and Cellular biology
- Creator:
- Kim, Dalton Robert
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16465 and etdadmin_upload_977054
-
- Description:
- Multiple facets of the natural trajectory of glioma remain poorly understood, which results in a universally poor prognosis for patients with glioma. Many patients with glioma experience tumor-associated epilepsy (TAE) throughout their disease course, but the mechanism by which TAE occurs, who is at continued risk for TAE, and whether...
- Keyword:
- Glioma, Glioblastoma, Infiltration, IDH, and Seizure
- Subject:
- Oncology and Cellular biology
- Creator:
- Drumm, Michael Raymond
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16570 and etdadmin_upload_985850
-
- Description:
- The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting the potential clinical applicability of this technology in regenerative medicine. We hypothesized that this issue is due...
- Keyword:
- calcium cycling, spontaneous contraction, high-throughput, cardiomyocyte, direct reprogramming, and fibroblast
- Subject:
- Biology, Cellular biology, and Developmental biology
- Creator:
- Romero Tejeda, Marisol
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 05/31/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_970274 and http://dissertations.umi.com/northwestern:16446
-
- Description:
- This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
- Keyword:
- protein design, cell-penetrating protein, protein folding stability, and synthetic biology
- Subject:
- Biology, Cellular biology, and Biophysics
- Creator:
- Kim, Tae-Eun
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_1008136 and http://dissertations.umi.com/northwestern:16683
-
- Description:
- This dissertation focuses on quantifying protein folding stability determinants and presenting initial experiments that can guide the development of a novel assay that identifies cell-penetrating miniproteins. First, despite over a century of scholarship on protein folding stability, applying this knowledge to design proteins computationally remains limited. Usually, protein designers generate...
- Keyword:
- protein design, cell-penetrating protein, synthetic biology, and protein folding stability
- Subject:
- Biology, Cellular biology, and Biophysics
- Creator:
- Kim, Tae-Eun
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 08/23/2023
- Date Created:
- 2023-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16695 and etdadmin_upload_1009800