Index Catalog // Arch : Northwestern University Institutional Repository

Design and Optimization of a Genome-Engineering Platform for Systems-Level Optimization of Synthetic Translation Systems

Description:: Cellular translation is responsible for the synthesis of proteins, a highly diverse class of macromolecules that form the basis of biological function. In Escherichia coli, harnessing and engineering of the biomolecular components of translation, such as ribosomes, transfer RNAs (tRNAs) and aminoacyl-tRNA synthetases, has led to both biotechnology products (i.e.,...
Keyword:: Genome engineering, Directed evolution, Synthetic biology, and Cell chassis development
Subject:: Bioengineering and Chemical engineering
Creator:: Gowland, Samuel Luke Walker
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/16/2023
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16336 and etdadmin_upload_943800

Directed Evolution of Protein-based Biomaterials Enabled by Advances in High-throughput Mechanical Testing and Protein Purification

Description:: Protein-based biomaterials are widely used in biomedical applications and mechanical support because of their novel structural flexibility, biocompatibility and mechanical properties. Protein-based biomaterials outperform traditional synthetic materials in various environments as traditional materials lack the diverse chemical functionalities that proteins offer. Novel bioinspired techniques such as directed evolution offer the...
Subject:: Bioengineering, Materials Science, and Chemical engineering
Creator:: Chen, Yusu
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16130 and etdadmin_upload_912201

High-Throughput Protein-Protein Interaction Screening Using Cell-Free Protein Synthesis

Description:: Protein-protein interactions are ubiquitous in living systems, and mediate important cellular processes from decision making to immunity against pathogens. Furthermore, protein-protein interactions are key to many protein therapeutics, pathogen diagnostics, and numerous synthetic biology applications. As a result, there has been significant effort to develop methods to express potential protein...
Keyword:: Minibinder, Antibodies, Diagnostics, Protein Protein Interactions, High-Throughput Screening, and Cell-Free Protein Synthesis
Subject:: Bioengineering and Chemical engineering
Creator:: hunt, Andrew
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_911343 and http://dissertations.umi.com/northwestern:16125

Modeling, Analysis, and Control of Heterogeneous Multicellular Oscillators

Description:: No two cells in a population are identical to each other. Cell populations are almost universally heterogeneous, with their heterogeneity or variability often underlying complex emergent behavior and phenotypes. Heterogeneity presents a challenge to the discovery, characterization, and control of multicellular systems. Heterogeneity exists across multiple scales, ranging from the...
Keyword:: Circadian Rhythms, Systems Biology, Control Theory, Dynamical Systems, and Mathematical Modeling
Subject:: Bioengineering and Chemical engineering
Creator:: Balakrishnan, Narasimhan
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_879749 and http://dissertations.umi.com/northwestern:15942

Enabling Exploration of CAR T-Cell Design and Integration of Social Justice Context into Chemical Engineering Courses

Description:: Chimeric antigen receptor (CAR) T-cell therapies marry advances in cellular engineering with personalized medicine to provide patient-specific, targeted cancer treatments. Though current CAR T-cell therapies successfully target blood cell cancers, treating solid tumors has proven to be more challenging. Solid-tumor CAR designs must overcome several challenges, including tumor microenvironment barriers...
Keyword:: agent-based model, CAR T-cell therapy, social justice, anti-racism diversity equity and inclusion, computational biology, and engineering education
Subject:: Bioengineering, Education, and Chemical engineering
Creator:: Prybutok, Alexis Nicole
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16073 and etdadmin_upload_902739

Engineering Protein Scaffolds as Programmable Cancer Therapeutics

Description:: Biological therapeutics have revolutionized the way we treat cancer due to their ability to target tumors discriminately, leaving healthy cells unaffected. However, our inability to tailor the structure of biologics may hamper their optimization for efficacy. This lack of programmability contributes to factors such as immunogenic responses, inability to penetrate...
Keyword:: Nanotechnology, Cancer therapy, Synthetic biology, Synthetic chemistry, Protein engineering, and Protein scaffolds
Subject:: Bioengineering, Chemistry, and Chemical engineering
Creator:: Kimmel, Blaise Russel
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/02/2022
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_852716 and http://dissertations.umi.com/northwestern:15804

Design of Engineered Ribosomes for Synthetic Biology

Description:: The Escherichia coli ribosome is a molecular machine capable of sequence-defined polymerization of -amino acids into proteins, a feat unmatched by any other current synthetic catalyst. It is complex in its structure, comprised of 3 RNA parts (the 5S, 16S, and 23S ribosomal RNAs) and 54 ribosomal proteins (r-proteins). Efforts...
Keyword:: Synthetic Biology, RNA Design, and Ribosome Engineering
Subject:: Bioengineering, Bioinformatics, and Chemical engineering
Creator:: Kim, Do Soon
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/06/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_831423 and http://dissertations.umi.com/northwestern:15634

Design and Optimization of a Field-Deployable Biosensing Platform for Measuring Water Quality

Description:: By 2030, up to half of the world’s population is projected to suffer from water insecurity: a chronic scarcity of potable water due to rapidly warming temperatures, increased agricultural demand, and pollution. The health impacts of contaminated water are profound: hundreds of thousands of global deaths each year are ascribed...
Keyword:: diagnostics, water quality, cell-free, and synthetic biology
Subject:: Bioengineering, Chemical engineering, and Public health
Creator:: Silverman, Adam Daniel
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15551 and etdadmin_upload_817796

Engineering the 1,2-Propanediol Utilization Bacterial Microcompartment to Develop a Tunable Nanobioreactor

Description:: While metabolic engineering can enable the sustainable bioproduction of new materials, efforts are often impeded by pathway bottlenecks. To mitigate the effects of toxic or reactive intermediates and resource competition resulting from heterologous pathway incorporation, bacterial microcompartments (MCPs) have recently been considered for engineered compartmentalization in bacterial host organisms. MCPs...
Keyword:: Tag Engineering, Metabolic Engineering, Cargo Encapsulation, Bacterial Microcompartments, and Genomic Integration
Subject:: Bioengineering and Chemical engineering
Creator:: Nichols, Taylor Marie
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/28/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_802174 and http://dissertations.umi.com/northwestern:15500

Engineering Scalable Microenvironments to Enhance Ex Vivo Megakaryocyte Production and Platelet Release

Description:: Currently, platelet transfusions, possessing profound clinical importance in the clotting of blood and healing of wounds, are entirely derived from human volunteer donors. This approach is limited by a 5-day shelf life, the potential risk of contamination, and differences in donor/recipient immunology. In vivo, platelets are formed when bone marrow...
Keyword:: Applied sciences, Biological sciences, Megakaryocyte, Cell therapies, Computational fluid dynamics, and Microfluidic bioreactor
Subject:: Bioengineering, Chemical engineering, and Cellular biology
Creator:: Martinez, Andres Felipe
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2019-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_657405 and http://dissertations.umi.com/northwestern:14571

Microfluidics on Self-Assembled Monolayers for Analyzing Biological and Chemical Reactions

Description:: Recent advances in combinatorial chemistry, synthetic biology, and ‘omics’ research require high-throughput methods for performing and analyzing thousands to millions of reactions in one day. However, it is a challenge to engineer high-throughput systems that can autonomously conduct and analyze such a large number of reactions in a generalizable and...
Keyword:: Self-assembled monolayers, Kinetics, Spatiotemporal, SAMDI Mass Spectrometry, MALDI Imaging Mass Spectrometry, and Microfluidics
Subject:: Bioengineering, Chemistry, and Chemical engineering
Creator:: Grant, Jennifer
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:14444 and etdadmin_upload_625853

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Design and Optimization of a Genome-Engineering Platform for Systems-Level Optimization of Synthetic Translation Systems

Directed Evolution of Protein-based Biomaterials Enabled by Advances in High-throughput Mechanical Testing and Protein Purification

High-Throughput Protein-Protein Interaction Screening Using Cell-Free Protein Synthesis

Modeling, Analysis, and Control of Heterogeneous Multicellular Oscillators

Enabling Exploration of CAR T-Cell Design and Integration of Social Justice Context into Chemical Engineering Courses

Engineering Protein Scaffolds as Programmable Cancer Therapeutics

Design of Engineered Ribosomes for Synthetic Biology

Design and Optimization of a Field-Deployable Biosensing Platform for Measuring Water Quality

Engineering the 1,2-Propanediol Utilization Bacterial Microcompartment to Develop a Tunable Nanobioreactor

Engineering Scalable Microenvironments to Enhance Ex Vivo Megakaryocyte Production and Platelet Release

Microfluidics on Self-Assembled Monolayers for Analyzing Biological and Chemical Reactions

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