Index Catalog // Arch : Northwestern University Institutional Repository

Description:: CD99-Like 2 (CD99L2) is a 52 kDa type I glycoprotein expressed on leukocytes and endothelial cells as well as other cell types in mice. It is related to CD99, although it shows only 32% sequence identity. CD99L2 has been shown to play a role in leukocyte extravasation in mice under...
Keyword:: Inflammation, Transmigration, Leukocyte, PECAM, Endothelial Cell, and CD99-like 2
Subject:: Pathology, Molecular biology, and Immunology
Creator:: Rutledge, Nakisha S
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 06/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_903372 and http://dissertations.umi.com/northwestern:16098

Description:: Cytokines made by macrophages play a critical role in determining the course of Legionella pneumophila infection. Prior, murine-based modeling indicated that the cytokine response initiated upon recognition of L. pneumophila involves a subset of Toll-like receptors, namely TLR2, TLR5, and TLR9. Using shRNA/siRNA knockdowns and subsequently CRISPR/Cas9 knockouts (KO), I...
Keyword:: TLR4, Legionella pneumophila, Macrophage , Toll-like Receptors, and TLR3
Subject:: Microbiology, Molecular biology, and Immunology
Creator:: Grigoryeva, Lubov Sergeevna
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 10/07/2021
Date Created:: 2021-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_839521 and http://dissertations.umi.com/northwestern:15684

Description:: When properly regulated, inflammation leads to the recruitment and activation of circulating leukocytes to maintain and restore tissue homeostasis. Although this process is critical for successful wound healing and the elimination of pathogens and infections, misdirected inflammation can exacerbate pathology and cause substantial morbidity and mortality. Inflammation a fundamental process...
Keyword:: Calmodulin Kinase II, Transendothelial Migration, Leukocyte-Endothelial Cell Interactions, IQGAP1, Calcium, and Calmodulin
Subject:: Pathology, Molecular biology, and Immunology
Creator:: Dalal, Prarthana
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_767426 and http://dissertations.umi.com/northwestern:15311

Description:: This dissertation focuses on the development of quantitative approaches for characterizing endogenous signaling pathways and designing new pathways in mammalian cells. I demonstrate how mathematical descriptions that are formulated to explain gene expression patterns can also serve as a powerful springboard for deeper analyses into the properties and functions of...
Keyword:: macrophage, systems biology, receptor, computational biology, transcription factor, and synthetic biology
Subject:: Bioengineering, Molecular biology, and Immunology
Creator:: Muldoon, Joseph Jacob
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15256 and etdadmin_upload_764084

Description:: Bacteria often coordinate virulence factors to fine-tune the host response during infection. These coordinated events can include toxins counteracting or amplifying effects of another toxin or though regulating the stability of virulence factors to remove their function once it is no longer needed. Multifunctional autoprocessing repeats-in toxin (MARTX) toxins are...
Keyword:: Toxin, MAPK, IL-8, Vibrio vulnificus, MARTX, and Vibrio cholera
Subject:: Microbiology, Molecular biology, and Immunology
Creator:: Woida, Patrick James
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/01/2021
Date Created:: 2020-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:15369 and etdadmin_upload_778406

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