Sufficient vocal fold superficial hydration is indispensable to maintain normal vocal function and protect vocal fold epithelium against invasion of pathogenic agents. Vocal fold surface hydration is probably regulated by its electrophysiological properties. We hypothesized that the tight junction (TJ)-related paracellular barrier contributes to the maintenance of those properties. Therefore,...
Solder joint integrity is recognized as a key issue in the reliability of flip chip and ball grid arrays in integrated circuit packages. Significant reductions in the solder-joint interconnect size results in both the increased volume fraction of brittle intermetallics in the joint and joule heating and electromigration failure due...
T-cell activation is an essential step of the immune response, yet the cellular and molecular events underlying this complex process are not fully understood. Significantly, a comparative genome-scale transcriptional analysis of two T-cell subsets and the natural-mixed CD3+ population remains unexplored. Using microarrays, we investigated the temporal global transcriptional profile...
The genetic information in DNA is transcribed to mRNA and then translated to proteins, which form the building blocks of life. Translation, or protein synthesis, is hence a central cellular process. Decades of experimentation have elucidated a vast wealth of molecular information about discrete translation steps, but the sheer complexity...
The studies in this thesis are directed towards defining the signaling mechanisms that regulate astrogliosis after SCI and towards developing potential therapeutic techniques for modifying this process. The central hypothesis is that alteration of the extracellular milieu after SCI can limit the deleterious effects of glial scar formation and enhance...
Assembly of the large and small subunits of the <em>E. coli</em> ribosome is a complicated process that involves transcription, processing, and modifying of the ribosomal RNA, the binding of ribosomal proteins, and the folding of the particles into complex structures. A number of ribosome assembly factors, including maturation factors, GTPases,...
The light field is a 4D function that describes the flow of light in all directions through every point in free space. Digital cameras only capture a 2D projection of the 4D light field entering the camera lens. In this dissertation I modify the light field as it enters a...
I examine how consumers' purchase' decisions and intentions of purchases are affected by uncertainty about future deals (temporary price cuts or sales) for a product and how these results affect retailers' optimal pricing and marketing strategies. First I look at the effects of uncertainty about the timing of deals (i.e....
The promise of a clean, renewable, and abundant energy supply make the efficient conversion of solar energy to electricity a compelling scientific and societal goal. In the following chapters, I will describe my efforts to advance one class of photovoltaic technology, dye-sensitized solar cells, by demonstration and characterization of unexplored...
The mechanisms governing selective CaCO3 crystal nucleation in living organisms remain unclear. For example, nacreous layers from the inner surfaces of shells are built as brick-and-mortar complexes of plate-like aragonite single crystals and organic layers. Unstable [001] surfaces of calcite columns in prismatic layers are also stabilized by organic molecules....