The ubiquitin-proteasome system degrades regulatory proteins and thereby controls a broad range of cellular processes such as the cell cycle, DNA-repair, gene transcription and signal transduction. The proteasome typically degrades its substrates completely into small peptides. However, biological exceptions do occur. For example, the activity of a handful of transcriptional...
The representation and communication of spatial information is important to the functioning of children and adults in the physical world. Yet little research has included both areas in the same studies. This research program was designed to investigate both the communication and representation of spatial information within a developmental context....
This dissertation expands on the existing disclosure theory by considering the monitoring role of a firm's disclosure as well as recognizing how a firm's disclosure is influenced by the firm's monitoring mechanisms. The first chapter of the dissertation examines the effect of corporate governance on a firm's earnings reporting process....
This dissertation is composed of readings of four novellas: two by the Swiss writer Gottfried Keller and two by the English novelist George Eliot. It focuses on the motif and concept of treasure (Schatz). Beginning with the figurative and rhetorical employment of "treasure" in the stories, each reading proceeds to...
Epstein-Barr virus (EBV) is a human gamma-herpesvirus that primarily infects B cells and epithelial cells. While the glycoproteins required for entry into these two cell types differ, the gH/gL glycoprotein complex is essential for entry into both epithelial and B cells. Analysis of gH protein sequences from three gamma-herpesviruses: EBV,...
RNA interference (RNAi) is a newly discovered gene control pathway that silences gene expression in response to double-stranded RNA. This sequence-specific downregulation occurs at the level of mRNA stability, and is directed by the double-stranded RNA trigger itself. RNAi can be separated into two distinct steps; during the initiation phase,...
Self-assembly is the process by which objects autonomously assemble into complexes. It is believed that self-assembly technology will ultimately permit the precise fabrication of complex nanostructures. Of particular interest are self-assembly systems that are highly programmable. That is, we can view a self-assembly system as analogous to a program, the...
This dissertation investigates the ways in which poetry encourages visual images in the reader. This investigation breaks new ground, for in the wake of behaviorist psychology and the linguistic turn in literary theory, literary critics have ignored and often spurned the visual imagination. The project uses Imagist poetry as a...
The study of III-Nitride based optoelectronics devices is a maturing field, but there are still many underdeveloped areas in which to make a contribution of new and original research. This work specifically targets the goals of realizing high-efficiency back-illuminated solar-blind photodetectors, solar-blind focal plane arrays, and visible- and solar-blind Avalanche...
Solid oxide fuel cells (SOFCs), renowned for their high electrical generation efficiency with low pollutant production, are promising for reducing global energy and environmental concerns. However, there are major barriers for SOFC commercialization. A primary challenge is reducing the capital cost of SOFC power plants to levels that can compete...